MKKS and PLCB4

		MKKS	PLCB4
Description		MKKS centrosomal shuttling protein	phospholipase C beta 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Motile Cilium Ciliary Basal Body Kinociliary Basal Body	Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Phosphatidylinositol Phospholipase C Activity
	Biological Process	Heart Looping Developmental Process Involved In Reproduction Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Leptin-mediated Signaling Pathway Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Animal Organ Development System Development Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Response To Inositol Non-motile Cilium Assembly	Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Phospholipase C-activating Endothelin Receptor Signaling Pathway
Pathways		BBSome-mediated cargo-targeting to cilium	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol G alpha (q) signalling events G alpha (q) signalling events
Drugs
Diseases		46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)
GWAS			Daytime sleep phenotypes ( 27126917) Evening vs. morning chronotype (self-assessed) ( 32579418) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Metabolite levels ( 23823483) Neutrophil count ( 20172861)
Interacting Genes		4 interacting genes: APP CDR2 PTN ZBED1	3 interacting genes: MEOX2 NLGN3 REL
Entrez ID		8195	5332
HPRD ID		05356	02885
Ensembl ID		ENSG00000125863	ENSG00000101333
Uniprot IDs		B7Z3W9 Q9NPJ1	A0A7P0MRI8 Q15147
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Long-term Synaptic Potentiation Response To Auditory Stimulus Molecular Function Activator Activity Dendrite Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Dendrite Development Phospholipase C-activating Endothelin Receptor Signaling Pathway Protein Autosumoylation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2 Receptor Complex Dendrite Regeneration Ossification Involved In Bone Remodeling Selenium Compound Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Modulation Of Chemical Synaptic Transmission Axon Midline Choice Point Recognition Recycling Endosome Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Positive Regulation Of Chemotaxis	Social Behavior DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Pattern Specification Process Segment Specification Somite Development Somite Specification Negative Regulation Of Interferon-beta Production NF-kappaB Complex Tonic Smooth Muscle Contraction Artery Smooth Muscle Contraction Regulation Of Cilium Beat Frequency Negative Regulation Of Appetite Pigment Granule Aggregation In Cell Center Kinociliary Basal Body Vascular Associated Smooth Muscle Contraction Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Convergent Extension Striatum Development Convergent Extension Involved In Gastrulation Leptin-mediated Signaling Pathway Response To Inositol Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Neurexin Family Protein Binding Asymmetric, Glutamatergic, Excitatory Synapse Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Respiratory System Process Inhibitory Postsynaptic Potential Neuron Cell-cell Adhesion Positive Regulation Of Glutamate Receptor Signaling Pathway Rhythmic Synaptic Transmission Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Regulation Of Glutamate Receptor Signaling Pathway Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Presynapse Assembly Presynaptic Membrane Organization Regulation Of Response To Food Sequence-specific DNA Binding Response To Leptin Presynapse Organization Establishment Of Melanosome Localization Chaperone-mediated Protein Complex Assembly Melanosome Localization Brain Morphogenesis Melanosome Transport Face Development Pigment Granule Transport
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