PLCB4

Description		phospholipase C beta 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Phosphatidylinositol Phospholipase C Activity
	Biological Process	Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Phospholipase C-activating Endothelin Receptor Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol G alpha (q) signalling events G alpha (q) signalling events
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Evening vs. morning chronotype (self-assessed) ( 32579418) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Metabolite levels ( 23823483) Neutrophil count ( 20172861)
Novel Interacting Genes		1 novel interacting genes: MKKS
Interacting Genes		3 interacting genes: MEOX2 NLGN3 REL
Entrez ID		5332
HPRD ID		02885
Ensembl ID		ENSG00000101333
Uniprot IDs		A0A7P0MRI8 Q15147
PDB IDs
Enriched GO Terms of Interacting Partners?		Social Behavior DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Pattern Specification Process Segment Specification Somite Development Somite Specification Negative Regulation Of Interferon-beta Production NF-kappaB Complex Tonic Smooth Muscle Contraction Artery Smooth Muscle Contraction Regulation Of Cilium Beat Frequency Negative Regulation Of Appetite Pigment Granule Aggregation In Cell Center Kinociliary Basal Body Vascular Associated Smooth Muscle Contraction Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Convergent Extension Striatum Development Convergent Extension Involved In Gastrulation Leptin-mediated Signaling Pathway Response To Inositol Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Neurexin Family Protein Binding Asymmetric, Glutamatergic, Excitatory Synapse Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Respiratory System Process Inhibitory Postsynaptic Potential Neuron Cell-cell Adhesion Positive Regulation Of Glutamate Receptor Signaling Pathway Rhythmic Synaptic Transmission Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Regulation Of Glutamate Receptor Signaling Pathway Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Presynapse Assembly Presynaptic Membrane Organization Regulation Of Response To Food Sequence-specific DNA Binding Response To Leptin Presynapse Organization Establishment Of Melanosome Localization Chaperone-mediated Protein Complex Assembly Melanosome Localization Brain Morphogenesis Melanosome Transport Face Development Pigment Granule Transport
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