MKKS and LAMP5

		MKKS	LAMP5
Description		MKKS centrosomal shuttling protein	lysosomal associated membrane protein family member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Motile Cilium Ciliary Basal Body Kinociliary Basal Body	Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Dendrite Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Growth Cone Membrane Dendrite Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Projection Synapse Recycling Endosome Recycling Endosome Membrane GABA-ergic Synapse
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Heart Looping Developmental Process Involved In Reproduction Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Leptin-mediated Signaling Pathway Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Animal Organ Development System Development Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Response To Inositol Non-motile Cilium Assembly	Establishment Of Protein Localization To Organelle Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)
GWAS
Interacting Genes		4 interacting genes: APP CDR2 PTN ZBED1	1 interacting genes: LTB4R2
Entrez ID		8195	24141
HPRD ID		05356	12736
Ensembl ID		ENSG00000125863	ENSG00000125869
Uniprot IDs		B7Z3W9 Q9NPJ1	Q9UJQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Long-term Synaptic Potentiation Response To Auditory Stimulus Molecular Function Activator Activity Dendrite Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Dendrite Development Phospholipase C-activating Endothelin Receptor Signaling Pathway Protein Autosumoylation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2 Receptor Complex Dendrite Regeneration Ossification Involved In Bone Remodeling Selenium Compound Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Modulation Of Chemical Synaptic Transmission Axon Midline Choice Point Recognition Recycling Endosome Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Positive Regulation Of Chemotaxis	Pigment Granule Aggregation In Cell Center Kinociliary Basal Body Response To Inositol Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Leukotriene Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Tonic Smooth Muscle Contraction Artery Smooth Muscle Contraction Negative Regulation Of Appetite Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Convergent Extension Involved In Gastrulation Leptin-mediated Signaling Pathway Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Keratinocyte Migration Negative Regulation Of Adenylate Cyclase Activity Convergent Extension Regulation Of Cilium Beat Frequency Vascular Associated Smooth Muscle Contraction Striatum Development Pigment Granule Localization Establishment Of Melanosome Localization Regulation Of Response To Food Chaperone-mediated Protein Complex Assembly Melanosome Localization Response To Leptin Brain Morphogenesis Melanosome Transport Face Development Pigment Granule Transport Regulation Of Appetite Detection Of Mechanical Stimulus Involved In Sensory Perception Vasoconstriction Regulation Of Response To Nutrient Levels Positive Regulation Of Multicellular Organism Growth Epithelial Cell Migration Regulation Of Cilium Movement G Protein-coupled Peptide Receptor Activity Photoreceptor Cell Maintenance Detection Of Mechanical Stimulus Negative Regulation Of Blood Pressure Negative Regulation Of Actin Filament Polymerization Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Vasodilation Social Behavior Smooth Muscle Contraction Heart Looping Regulation Of Multicellular Organism Growth Embryonic Heart Tube Morphogenesis
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