ISG20L2 and EML1

Number of citations of the paper that reports this interaction (PubMedID 19060904)
32

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		ISG20L2	EML1
Description		interferon stimulated exonuclease gene 20 like 2	EMAP like 1
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GO Annotations	Cellular Component	Nucleus Nucleolus	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle Mitotic Spindle Pole Mitotic Spindle Midzone
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Protein Binding Hydrolase Activity	Calcium Ion Binding Protein Binding Microtubule Binding Tubulin Binding
	Biological Process	DNA Metabolic Process RNA Processing Ribosome Biogenesis	Microtubule Cytoskeleton Organization Hematopoietic Progenitor Cell Differentiation Mitotic Spindle Organization Neuroblast Proliferation Brain Development
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Plateletcrit ( 27863252)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Depression in smokers ( 30219690) Pulse pressure ( 27841878) Scalp hair shape ( 26926045) Visceral fat ( 30942860)
Interacting Genes		2 interacting genes: EML1 HSPB1	7 interacting genes: GRID1 GRID2 ISG20L2 MTDH PTEN TUBA1A UBE3A
Entrez ID		81875	2009
HPRD ID		07788	03613
Ensembl ID		ENSG00000143319	ENSG00000066629
Uniprot IDs		Q9H9L3	O00423
PDB IDs		7YW5	4CI8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Kinase C Signaling Mitotic Spindle Midzone Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Contractile Muscle Fiber Microtubule-based Process Neuroblast Proliferation Cytoskeleton Microtubule Associated Complex Tubulin Binding Mitotic Spindle Pole Protein Localization To Synapse Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Protein Folding Chaperone Protein Kinase C Binding Platelet Aggregation Axon Cytoplasm Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Interleukin-1 Beta Production Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Axonal Transport Anterograde Axonal Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cornified Envelope Protein Refolding Proteasome Complex Homotypic Cell-cell Adhesion Positive Regulation Of Interleukin-1 Production	Dendritic Spine Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Synaptic Signaling Via Neuropeptide Forebrain Morphogenesis Chemical Synaptic Transmission Trans-synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Synaptic Signaling Prepulse Inhibition Startle Response Synapse Regulation Of Membrane Potential Monoatomic Ion Channel Activity Dentate Gyrus Development AMPA Glutamate Receptor Complex Glutamatergic Synapse Positive Regulation Of Excitatory Postsynaptic Potential Cell-cell Signaling Signaling Postsynaptic Membrane Cell Communication Synapse Organization Modulation Of Excitatory Postsynaptic Potential Signaling Receptor Activity Learning Or Memory Social Behavior Visual Learning Regulation Of Synapse Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Visual Behavior Cognition Negative Regulation Of Synaptic Vesicle Clustering Sperm Entry Positive Regulation Of Golgi Lumen Acidification Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels PDZ Domain Binding Futile Creatine Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration
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