AMN and TECPR2

		AMN	TECPR2
Description		amnion associated transmembrane protein	tectonin beta-propeller repeat containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Plasma Membrane Clathrin-coated Pit Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Microvillus Membrane Protein-containing Complex Receptor Complex Apical Part Of Cell Extracellular Exosome	Cytoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding Cargo Receptor Activity	Protein Binding
	Biological Process	Receptor-mediated Endocytosis Intracellular Protein Localization Cobalamin Metabolic Process Protein Transport Cobalamin Transport Golgi To Plasma Membrane Protein Transport Renal Protein Absorption	Autophagy Protein Exit From Endoplasmic Reticulum
Pathways		Defective AMN causes MGA1 Defective CUBN causes MGA1 HDL clearance Uptake of dietary cobalamins into enterocytes
Drugs		Hydroxocobalamin
Diseases
GWAS		Body mass index ( 26426971)	Appendicular lean mass ( 33097823) Birdshot chorioretinopathy ( 24957906) Body mass index ( 26426971) Platelet count ( 27863252) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: STAMBP	1 interacting genes: CCR2
Entrez ID		81693	9895
HPRD ID		09314	17184
Ensembl ID		ENSG00000166126	ENSG00000196663
Uniprot IDs		B3KP64 Q9BXJ7	O15040
PDB IDs		6GJE
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Chemokine (C-C Motif) Ligand 12 Binding Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 2 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Endocytosis Positive Regulation Of Monocyte Extravasation Neutrophil Clearance Monocyte Extravasation Renal Protein Absorption Cobalamin Transport Import Into Cell Cobalamin Metabolic Process Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Glial Cell Migration Negative Regulation Of Adenylate Cyclase Activity Inflammatory Response To Wounding Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Negative Regulation Of Type 2 Immune Response Positive Regulation Of Cellular Extravasation T Cell Chemotaxis Dendritic Cell Chemotaxis Positive Regulation Of T-helper 1 Type Immune Response Cellular Extravasation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Chemokine Receptor Activity Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Lymphocyte Chemotaxis Dendritic Cell Migration Leukocyte Adhesion To Vascular Endothelial Cell Macrophage Migration Monocyte Chemotaxis C-C Chemokine Binding Regulation Of Lymphocyte Chemotaxis C-C Chemokine Receptor Activity Lymphocyte Chemotaxis
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