MPO

Name	myeloperoxidase
Structure
Novel Interactors	1 novel interactors: IRS2
Interactors	3 interactors: CEBPA CP PTP4A2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Lysosome Secretory Granule Azurophil Granule Lumen Azurophil Granule Extracellular Exosome Phagocytic Vesicle Lumen
	Molecular Function	Chromatin Binding Peroxidase Activity Protein Binding Heparin Binding Oxidoreductase Activity Heme Binding Metal Ion Binding
	Biological Process	Response To Yeast Hypochlorous Acid Biosynthetic Process Respiratory Burst Involved In Defense Response Defense Response Response To Oxidative Stress Response To Mechanical Stimulus Removal Of Superoxide Radicals Response To Food Response To Lipopolysaccharide Low-density Lipoprotein Particle Remodeling Defense Response To Bacterium Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Defense Response To Fungus Response To Gold Nanoparticle
Pathways	Neutrophil degranulation Events associated with phagocytolytic activity of PMN cells
Drugs	Cefdinir Levocarnitine Melatonin Nomifensine
Diseases	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS	Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Blood protein levels in cardiovascular risk ( 28369058 ) Circulating myeloperoxidase levels (plasma) ( 23620142 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 27863252 32888494 ) Multiple sclerosis ( 31604244 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 27863252 )
Entrez ID	4353
HPRD ID	06102
Ensembl ID	ENSG00000005381
Uniprot IDs	P05164
PDB IDs	1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P 3ZS0 3ZS1 4C1M 4DL1 4EJX 5FIW 5MFA 5UZU 6AZP 6BMT 7OIH
GO Terms Enriched among Interactors ?	Carbohydrate Homeostasis CHOP-C/EBP Complex Glucose Homeostasis Lipid Homeostasis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Chemical Homeostasis Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Phospholipid-hydroperoxide Glutathione Peroxidase Activity Ferroxidase Activity Oxidoreductase Activity, Acting On Metal Ions Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Protein Domain Specific Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Phenylpropanoid Gland Development Homeostatic Process Phosphatidylinositol 3-kinase Activator Activity Fat Cell Proliferation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Positive Regulation Of Fatty Acid Beta-oxidation Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Intracellular Copper Ion Homeostasis Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Fatty Acid Oxidation Response To Endothelin Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cellular Response To Endothelin Type B Pancreatic Cell Proliferation