EPC1 and MBTD1

Number of citations of the paper that reports this interaction (PubMedID 27153538)
41

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		EPC1	MBTD1
Description		enhancer of polycomb 1	mbt domain containing 1
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GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Body Nuclear Membrane Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Site Of Double-strand Break	Nucleosome Nucleus Chromosome NuA4 Histone Acetyltransferase Complex Site Of Double-strand Break
	Molecular Function	Protein Binding Chromatin-protein Adaptor Activity Enzyme-substrate Adaptor Activity	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone H4K20me2 Reader Activity Histone H4K20me1 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Spermatid Development Cell Differentiation Sperm DNA Condensation Regulation Of Apoptotic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Skeletal System Development Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		HATs acetylate histones Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Metabolite levels ( 23823483) Platelet distribution width ( 27863252 32888494) Sexual dysfunction (female) ( 22509378) Waist-hip index ( 34021172)	Bipolar disorder ( 31043756) Coronary artery disease ( 33020668) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: CHRM5 E2F6 HOPX KRT15 MBTD1 RINT1 SYCE1L TRIM27	3 interacting genes: EPC1 H4C1 TULP3
Entrez ID		80314	54799
HPRD ID		09941	14369
Ensembl ID		ENSG00000120616	ENSG00000011258
Uniprot IDs		Q9H2F5	Q05BQ5
PDB IDs		6NFX 8QR1 8XVG 8XVT 9C57 9C62 9C6N	3FEO 4C5I 6NFX
Enriched GO Terms of Interacting Partners?			Nucleolus Intraciliary Transport Particle A Binding Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Bronchus Morphogenesis Nucleosome Piccolo Histone Acetyltransferase Complex Pwp2p-containing Subcomplex Of 90S Preribosome Nuclear Membrane Embryonic Neurocranium Morphogenesis Neural Tube Formation Nucleoplasm Ganglion Development 9+0 Non-motile Cilium Embryonic Camera-type Eye Development Dorsal/ventral Neural Tube Patterning CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Enzyme-substrate Adaptor Activity Sperm DNA Condensation Chromatin-protein Adaptor Activity
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