FRAS1 and PAQR3

		FRAS1	PAQR3
Description		Fraser extracellular matrix complex subunit 1	progestin and adipoQ receptor family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Basement Membrane Plasma Membrane Membrane Extracellular Matrix	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding	Protein Binding Protein-membrane Adaptor Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Morphogenesis Of An Epithelium Metanephros Morphogenesis Cell Communication Anatomical Structure Morphogenesis Protein Transport Embryonic Limb Morphogenesis Skin Development Animal Organ Development System Development Roof Of Mouth Development	Negative Regulation Of Protein Phosphorylation NLS-bearing Protein Import Into Nucleus Negative Regulation Of Neuron Projection Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Protein Localization To Golgi Apparatus Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Cholesterol Biosynthetic Process Protein Maturation Positive Regulation Of SREBP Signaling Pathway
Pathways			Negative regulation of MAPK pathway
Drugs
Diseases		Fraser syndrome
GWAS		Blond vs. brown/black hair color ( 30531825) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology ( 19896111) Hair shape ( 29220522) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lung function (FEV1/FVC) ( 30804560) Night sleep phenotypes ( 27126917) QT interval ( 29213071) Response to carboplatin in ovarian cancer (MTT IC50) ( 27047539) Retinal detachment or retinal break ( 31816047) Uric acid levels ( 23703922)	Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Parkinson's disease ( 26227905)
Interacting Genes			3 interacting genes: BTRC PPARA RAD23B
Entrez ID		80144	152559
HPRD ID		06382	17819
Ensembl ID		ENSG00000138759	ENSG00000163291
Uniprot IDs		Q86XX4	Q6TCH7
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-like Ligase-substrate Adaptor Activity Protein-N-terminal-alanine Acetyltransferase Activity Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Positive Regulation Of SREBP Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity NatA Complex Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Protein Maturation Regulation Of SREBP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process N-terminal Protein Amino Acid Acetylation Peroxisome Proliferator Activated Receptor Signaling Pathway	Negative Regulation Of Appetite Response To Nutrient Levels Negative Regulation Of Glycolytic Process Regulation Of Circadian Rhythm Cellular Response To Fructose Stimulus Animal Organ Development Negative Regulation Of Cholesterol Storage Regulation Of Response To Food MDM2/MDM4 Family Protein Binding Enamel Mineralization Response To Fructose Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Catabolic Process Regulation Of Transformation Of Host Cell By Virus Cellular Response To Nutrient Levels Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of ATP Biosynthetic Process Tooth Mineralization Rhythmic Process NFAT Protein Binding Positive Regulation Of Transformation Of Host Cell By Virus Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of ATP Biosynthetic Process Behavioral Response To Nicotine Positive Regulation Of Fatty Acid Beta-oxidation Mitogen-activated Protein Kinase Kinase Kinase Binding Positive Regulation Of Fatty Acid Oxidation Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process DNA Damage Sensor Activity Cellular Response To Interleukin-7 Proteasomal Protein Catabolic Process Proteasome Binding XPC Complex Regulation Of Protein Catabolic Process Response To Interleukin-7 Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Circadian Rhythm Ubiquitin Ligase Activator Activity Mammary Gland Epithelial Cell Proliferation Morphogenesis Of An Epithelium Protein Phosphorylated Amino Acid Binding Tissue Morphogenesis Positive Regulation Of T Cell Receptor Signaling Pathway
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