PTGES2 and C9orf78

		PTGES2	C9orf78
Description		prostaglandin E synthase 2	chromosome 9 open reading frame 78
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm	Chromosome, Centromeric Region Nucleus Nucleoplasm Spliceosomal Complex Chromosome Cytosol
	Molecular Function	DNA Binding Protein Binding Lyase Activity Isomerase Activity Heme Binding 12-hydroxyheptadecatrienoic Acid Synthase Activity Glutathione Binding Prostaglandin-E Synthase Activity	RNA Binding Protein Binding U5 SnRNA Binding
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Positive Regulation Of DNA-templated Transcription Prostanoid Biosynthetic Process Secretion	MRNA Splicing, Via Spliceosome MRNA Processing Chromosome Segregation RNA Splicing MRNA Cis Splicing, Via Spliceosome Regulation Of Homologous Chromosome Segregation
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Neutrophil degranulation	mRNA Splicing - Major Pathway
Drugs
Diseases		Penile cancer
GWAS		Body mass index ( 26426971)
Interacting Genes		6 interacting genes: ADRB2 CEBPB CFAP141 EXOSC10 HSPA13 PTGFR	6 interacting genes: APP FCHSD2 MAPK11 SMURF1 SUPT5H TAB1
Entrez ID		80142	51759
HPRD ID		07458	10803
Ensembl ID		ENSG00000148334	ENSG00000136819
Uniprot IDs		A0A7I2V5X6 A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7	Q9NZ63
PDB IDs			7OS2 8C6J 9FMD
Enriched GO Terms of Interacting Partners?		Regulation Of Sodium-dependent Phosphate Transport Regulation Of Phosphate Transport Brown Fat Cell Differentiation Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential Photoreactive Repair Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Prostaglandin F Receptor Activity Beta2-adrenergic Receptor Activity Granuloma Formation C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis T-helper 1 Cell Activation Kinase Binding CHOP-C/EBP Complex Positive Regulation Of Sodium-dependent Phosphate Transport Cry-Per Complex Regulation Of Homologous Chromosome Segregation U5 SnRNA Binding Norepinephrine Binding Negative Regulation Of Glucocorticoid Secretion Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Response To Psychosocial Stress Fat Cell Differentiation Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway SnRNA Catabolic Process CUT Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagosome Maturation Regulation Of Cold-induced Thermogenesis Heat Generation Nucleic Acid Metabolic Process Hepatocyte Proliferation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Blue Light Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway	Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Clathrin-coated Pit Stereocilium Shaft Engulfment Of Target By Autophagosome Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Interleukin-1 Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Positive Regulation Of Cytokine Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process DSIF Complex 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Regulation Of Growth Recycling Endosome Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Supramolecular Fiber Organization Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
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