L2HGDH and NIN

		L2HGDH	NIN
Description		L-2-hydroxyglutarate dehydrogenase	ninein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane	Pericentriolar Material Spindle Pole Nucleoplasm Nucleolus Cytoplasm Centrosome Centriole Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Axon Dendrite Ciliary Basal Body Axonal Growth Cone Apical Part Of Cell Mitotic Spindle Mitotic Spindle Pole Ciliary Transition Fiber Centriolar Subdistal Appendage
	Molecular Function	Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors 2-hydroxyglutarate Dehydrogenase Activity	Nucleotide Binding Calcium Ion Binding Protein Binding GTP Binding Microtubule Minus-end Binding
	Biological Process	2-oxoglutarate Metabolic Process Small Molecule Metabolic Process	Intracellular Protein Localization Centriole-centriole Cohesion Corpus Callosum Morphogenesis Corticospinal Tract Morphogenesis Microtubule Anchoring At Centrosome Collateral Sprouting Positive Regulation Of Axonogenesis Centrosome Localization Centrosome-templated Microtubule Nucleation
Pathways		Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462 31152163 31451708) Liver enzyme levels (alanine transaminase) ( 33972514) Periodontal disease-related phenotype (Socransky) ( 24347629) Serum metabolite levels ( 33031748) Systolic blood pressure ( 30224653)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Cognitive performance ( 20125193) Diastolic blood pressure ( 30578418) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 27863252) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Rectal cancer ( 33632709) Refractive error ( 32231278) Schizophrenia ( 33169155) Stroke ( 32693751) Systolic blood pressure ( 30578418)
Interacting Genes		1 interacting genes: SLC25A21-AS1	17 interacting genes: ABI1 AUNIP AURKA BICD1 GSK3B GTSE1 KLC1 PIAS1 PRKACA PRPF6 RBM10 RTRAF SNW1 SUMO1 UBE2I UTP14A YWHAE
Entrez ID		79944	51199
HPRD ID		12640	09785
Ensembl ID		ENSG00000087299	ENSG00000100503
Uniprot IDs		Q9H9P8	C9J066 E9PN67 Q5XUU0 Q8N4C6
PDB IDs
Enriched GO Terms of Interacting Partners?		Corticospinal Tract Morphogenesis Ciliary Basal Body Centriolar Subdistal Appendage Ciliary Transition Fiber Microtubule Nucleation By Microtubule Organizing Center Corpus Callosum Morphogenesis Centrosome-templated Microtubule Nucleation Establishment Of Left/right Asymmetry Microtubule Anchoring At Centrosome Centriole-centriole Cohesion Microtubule Minus-end Binding Microtubule Anchoring At Microtubule Organizing Center Collateral Sprouting Dynein Axonemal Particle Outer Dynein Arm Assembly Inner Dynein Arm Assembly Axonal Growth Cone Pericentriolar Material Central Nervous System Projection Neuron Axonogenesis Microtubule Anchoring Microtubule Nucleation Central Nervous System Neuron Axonogenesis Centrosome Localization Protein Folding Chaperone Complex Mitotic Spindle Pole Microtubule-based Process Axonemal Dynein Complex Assembly Epithelial Cilium Movement Involved In Extracellular Fluid Movement Nucleolus Extracellular Transport Cytoplasmic Microtubule	Regulation Of Nucleocytoplasmic Transport Nuclear Speck Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Export From Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Small Protein Activating Enzyme Binding PML Body Centrosome Peptidyl-serine Phosphorylation Regulation Of Intracellular Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome Regulation Of Intracellular Protein Transport Cellular Response To Heat Protein Sumoylation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Processing Regulation Of Protein Localization To Centrosome RNA Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Localization To Organelle Dynactin Binding Positive Regulation Of Protein Catabolic Process Enzyme Binding Response To Heat Positive Regulation Of Intracellular Protein Transport Intracellular Potassium Ion Homeostasis Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Transcription Factor Binding SUMO Transferase Activity Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Metabolic Process Regulation Of Cellular Localization Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Protein Metabolic Process Nuclear Export Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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