SYNPO2L and ZNF503

		SYNPO2L	ZNF503
Description		synaptopodin 2 like	zinc finger protein 503
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Z Disc Organelle	Nucleus
	Molecular Function	Actin Binding Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Heart Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Rho Protein Signal Transduction Sarcomere Organization Positive Regulation Of Stress Fiber Assembly	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation G1 To G0 Transition Involved In Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 22544366 28416818 29290336 29892015 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Incident atrial fibrillation ( 28416818) Mean arterial pressure ( 27618448) PR interval ( 32439900) Systolic blood pressure ( 27618452)	Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926)
Interacting Genes		7 interacting genes: ACTN1 ACTN2 ACTN3 GOLGA2 PSMB4 SH3RF1 SORBS3	10 interacting genes: ARID5A ATN1 DTX2 FOXH1 KRTAP19-1 KRTAP3-3 KRTAP6-2 PROP1 TENT5B TLE5
Entrez ID		79933	84858
HPRD ID		15457	15811
Ensembl ID		ENSG00000166317	ENSG00000165655
Uniprot IDs		Q9H987	Q96F45
PDB IDs
Enriched GO Terms of Interacting Partners?		Pseudopodium Focal Adhesion Assembly Cell-substrate Junction Organization Cell-substrate Junction Assembly Sarcomere Cortical Actin Cytoskeleton Actin Filament Muscle Cell Development Vinculin Binding Transmembrane Transporter Binding Cytoskeleton Organization Focal Adhesion Z Disc Integrin Binding Actin Filament Binding Cell Junction Structural Constituent Of Muscle Cell Junction Assembly Actin Cytoskeleton Brush Border Cytoskeletal Protein Binding Platelet Alpha Granule Lumen Actin Cytoskeleton Organization Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Actin Binding Actin Filament-based Process Regulation Of Primary Metabolic Process Structural Constituent Of Postsynapse Titin Z Domain Binding Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Cell Junction Organization Platelet Morphogenesis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Cell Projection Microspike Assembly Positive Regulation Of Protein Glycosylation Organelle Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cytoskeleton Calcium Ion Binding Actin Filament Network Formation Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity Positive Regulation Of Cytoskeleton Organization FATZ Binding	Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Androgen Receptor Binding Intermediate Filament Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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