SETD6 and NOD2

		SETD6	NOD2
Description		SET domain containing 6, protein lysine methyltransferase	nucleotide binding oligomerization domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Vesicle Protein-containing Complex Phagocytic Vesicle
	Molecular Function	Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity NF-kappaB Binding S-adenosyl-L-methionine Binding	Nucleotide Binding Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Pattern Recognition Receptor Activity Peptidoglycan Binding Ubiquitin Binding Anion Binding ADP Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding Carbohydrate Derivative Binding
	Biological Process	Peptidyl-lysine Monomethylation Stem Cell Population Maintenance Negative Regulation Of NF-kappaB Transcription Factor Activity Methylation Stem Cell Differentiation Regulation Of Inflammatory Response	Temperature Homeostasis Pattern Recognition Receptor Signaling Pathway Adaptive Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Autophagy Defense Response Canonical NF-kappaB Signal Transduction Response To Nutrient Positive Regulation Of Cell Population Proliferation Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Intestinal Stem Cell Homeostasis P38MAPK Cascade Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Host-mediated Modulation Of Intestinal Microbiota Composition Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Protein Linear Polyubiquitination Antibacterial Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mitophagy Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Macrophage Apoptotic Process
Pathways		PKMTs methylate histone lysines	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs			Mifamurtide
Diseases			Crohn's disease Blau syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure ( 30578418) QT interval ( 29213071) Schizophrenia ( 29483656)	Asthma ( 32296059 31361310 30929738) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17804789 28067908 23128233 22936669 22412388 21102463 20570966 18587394 17554300) Inflammatory bowel disease ( 28067908 18758464) Leprosy ( 25642632 27976721 20018961) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		1 interacting genes: ATXN1	38 interacting genes: ALPI ANKHD1 ANXA2 ATG16L1 C10orf67 CCL13 CHMP4B CHMP5 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP
Entrez ID		79918	64127
HPRD ID		07956	05810
Ensembl ID		ENSG00000103037	ENSG00000167207
Uniprot IDs		Q8TBK2	A0A286YF65 Q9HC29
PDB IDs		3QXY 3RC0
Enriched GO Terms of Interacting Partners?		Poly(G) Binding POZ Domain Binding Nuclear Inclusion Body Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Detection Of Molecule Of Bacterial Origin Positive Regulation Of Gamma-delta T Cell Activation Detection Of Bacterium Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Detection Of Muramyl Dipeptide Detection Of Peptidoglycan Intestinal Stem Cell Homeostasis Cellular Response To Peptidoglycan Protein Linear Polyubiquitination Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Carbohydrate Derivative Binding Extrinsic Component Of Plasma Membrane Cellular Response To Muramyl Dipeptide Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Dendritic Cell Cytokine Production Response To Peptidoglycan Muramyl Dipeptide Binding Anion Binding Host-mediated Modulation Of Intestinal Microbiota Composition CMG Complex GINS Complex Regulation Of Protein K63-linked Ubiquitination CARD Domain Binding Peptidoglycan Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Type 2 Immune Response Positive Regulation Of Protein Polyubiquitination Antibacterial Innate Immune Response Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Antigen Processing And Presentation Positive Regulation Of Mitophagy Maintenance Of Gastrointestinal Epithelium Response To Muramyl Dipeptide Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Appetite P38MAPK Cascade Macromolecule Metabolic Process Positive Regulation Of Interleukin-17 Production Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Polyubiquitination	Response To Muramyl Dipeptide Cellular Response To Muramyl Dipeptide Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Muscle Thin Filament Tropomyosin Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nuclear Migration Response To External Biotic Stimulus Nucleus Localization Stress Fiber Cytosol Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Mitotic Spindle Organization Cellular Response To Lipopolysaccharide Innate Immune Response-activating Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Autophagy Autophagosome Maturation Cellular Response To Molecule Of Bacterial Origin C-terminal Protein Lipidation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Activation Of Innate Immune Response Autophagosome Membrane Intracellular Transport Canonical NF-kappaB Signal Transduction P38MAPK Cascade Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Deubiquitination Regulation Of Organelle Organization Vesicle Budding From Membrane Response To Lipid Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Protein Metabolic Process Organelle Localization Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Protein Linear Polyubiquitination Xenophagy Identical Protein Binding Regulation Of Protein Metabolic Process Cellular Localization Endosome Transport Via Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Response To Oxygen-containing Compound Positive Regulation Of Xenophagy Positive Regulation Of Organelle Organization
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