TREML2 and CSF2

		TREML2	CSF2
Description		triggering receptor expressed on myeloid cells like 2	colony stimulating factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Protein Binding Signaling Receptor Activity	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	T Cell Activation	Histamine Secretion Embryonic Placenta Development Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Epithelial Fluid Transport Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of DNA-templated Transcription Regulation Of Developmental Process Positive Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling
Drugs			KB002
Diseases
GWAS		Alzheimer's disease (late onset) ( 24162737) Blood protein levels ( 30072576) Monocyte count ( 27863252 32888494) Reticulocyte count ( 32888494) Type 2 diabetes ( 31049640) Waist circumference ( 28552196) White blood cell count ( 32888494)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Rheumatoid arthritis ( 22446963 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes			9 interacting genes: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 S100A6 S100P SDC2
Entrez ID		79865	1437
HPRD ID		11646	00734
Ensembl ID		ENSG00000112195	ENSG00000164400
Uniprot IDs		Q5T2D2	P04141
PDB IDs			1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS
Enriched GO Terms of Interacting Partners?		Regulation Of Behavior Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Positive Regulation Of Male Mating Behavior Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Response To Silicon Dioxide Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Hair Follicle Placode Formation Positive Regulation Of Podosome Assembly Positive Regulation Of Cytokine Production Regulation Of Podosome Assembly Positive Regulation Of Interleukin-23 Production Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Epithelial Fluid Transport Regulation Of Interleukin-23 Production Neutrophil Differentiation Histamine Transport Cellular Response To Lipid Histamine Secretion Cellular Response To Dopamine Negative Regulation Of Transcription By Competitive Promoter Binding Eyelid Development In Camera-type Eye Behavioral Response To Ethanol Deacetylase Activity Protein Lysine Deacetylase Activity Progesterone Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Dopamine Histone Deacetylase Activity, Hydrolytic Mechanism Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Negative Regulation Of Dendritic Spine Development ESC/E(Z) Complex Response To Caffeine Regulation Of Cytokine Production Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cell Population Proliferation Response To Lipid Negative Regulation Of Programmed Cell Death Embryonic Placenta Development Monocyte Differentiation Negative Regulation Of Apoptotic Process Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Cellular Response To Oxygen-containing Compound	Interleukin-3 Receptor Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Macrophage Cytokine Production Cytokine Receptor Activity External Side Of Plasma Membrane Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Extracellular Matrix Signaling Receptor Activity Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cytokine Binding Positive Regulation Of Bone Mineralization Translation Termination Factor Activity Cytoplasmic Translational Termination Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Apoptotic Process Positive Regulation Of Biomineral Tissue Development Immune System Process Positive Regulation Of Ossification Neural Crest Cell Migration Mesenchymal Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Cell Population Proliferation
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