SUGCT and NME8

		SUGCT	NME8
Description		succinyl-CoA:glutarate-CoA transferase	NME/NM23 family member 8
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Cytoplasm Cytosol Axoneme Nuclear Speck Sperm Flagellum Outer Dynein Arm Sperm Midpiece Sperm Principal Piece Sperm Cytoplasmic Droplet
	Molecular Function	Catalytic Activity Transferase Activity Succinate-hydroxymethylglutarate CoA-transferase Activity	Microtubule Binding 3'-5'-DNA Exonuclease Activity Hydrolase Activity
	Biological Process		DNA Catabolic Process Spermatogenesis Cell Differentiation Flagellated Sperm Motility Cellular Response To Reactive Oxygen Species Cilium Assembly
Pathways
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		A body shape index ( 34021172) Asthma ( 34103634) Gestational age at birth (child effect) ( 31194736) Gut microbiota relative abundance (Dorea) ( 33208821) Haemorrhoidal disease ( 33888516) Pancreatic cancer ( 26098869 29422604) Postoperative myocardial infarction after cardiac surgery ( 30678657) Pre-treatment viral load in HIV-1 infection ( 31219150) Prostate cancer ( 29892016) Pulse pressure ( 28135244 29403010 30487518) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30617256) Periodontitis ( 25672891)
Interacting Genes			2 interacting genes: APP RIPK3
Entrez ID		79783	51314
HPRD ID		09859	16243
Ensembl ID		ENSG00000175600	ENSG00000086288
Uniprot IDs		Q9HAC7	Q8N427
PDB IDs		9BR6 9BR7
Enriched GO Terms of Interacting Partners?		Sperm Cytoplasmic Droplet Outer Dynein Arm 3'-5'-DNA Exonuclease Activity DNA Catabolic Process Sperm Principal Piece Sperm Midpiece Cellular Response To Reactive Oxygen Species Sperm Flagellum Sperm Motility Flagellated Sperm Motility Axoneme Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Response To Reactive Oxygen Species Cilium Movement Cellular Response To Oxidative Stress	Amyloid Fibril Formation Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Regulation Of Type II Interferon Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Regulation Of Lymphocyte Migration Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Reactive Oxygen Species Metabolic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of T Cell Migration Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Execution Phase Of Necroptosis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Succinate-hydroxymethylglutarate CoA-transferase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Leukocyte Migration Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Activation-induced Cell Death Of T Cells Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Positive Regulation Of Necroptotic Process BBSome Heparan Sulfate Binding Signaling Receptor Activator Activity
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