ZBBX and IFT80

		ZBBX	IFT80
Description		zinc finger B-box domain containing	intraflagellar transport 80
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Centrosome Cytoskeleton Cilium Intraciliary Transport Particle B Ciliary Basal Body Cell Projection Ciliary Tip 9+0 Non-motile Cilium
	Molecular Function	Zinc Ion Binding Metal Ion Binding
	Biological Process		Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Apoptotic Process Establishment Or Maintenance Of Cell Polarity Smoothened Signaling Pathway Canonical NF-kappaB Signal Transduction Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Tissue Development Gene Expression Proteasomal Protein Catabolic Process Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Spinal Cord Development Osteoclast Differentiation Osteoblast Proliferation Multicellular Organism Growth Non-canonical Wnt Signaling Pathway Bone Mineralization Involved In Bone Maturation Intraciliary Anterograde Transport Odontogenesis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Keratinocyte Proliferation Tooth Eruption Cilium Organization Stem Cell Differentiation Protein Stabilization Cartilage Development Limb Development Cilium Assembly Bone Development Bone Morphogenesis Articular Cartilage Development Odontoblast Differentiation Stem Cell Proliferation Receptor Localization To Non-motile Cilium Response To Inositol Non-motile Cilium Assembly Cartilage Homeostasis Negative Regulation Of Non-canonical Wnt Signaling Pathway
Pathways			Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Fast beta electroencephalogram ( 28070124) Iris color (L* coordinate) ( 30895295) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Bipolar disorder ( 31043756) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Malaria ( 31844061)
Interacting Genes		1 interacting genes: MDFI	2 interacting genes: PLXNA2 UBXN10
Entrez ID		79740	57560
HPRD ID		08015	13853
Ensembl ID		ENSG00000169064	ENSG00000068885
Uniprot IDs		A8MT70 B7ZMD2	Q9P2H3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Tooth Eruption Articular Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Negative Regulation Of Non-canonical Wnt Signaling Pathway Bone Mineralization Involved In Bone Maturation Response To Inositol Cartilage Homeostasis Receptor Localization To Non-motile Cilium Animal Organ Morphogenesis Protein Localization To Ciliary Membrane Odontoblast Differentiation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Protein Localization To Non-motile Cilium Growth Plate Cartilage Development 9+0 Non-motile Cilium Osteoblast Proliferation Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Intraciliary Anterograde Transport Intraciliary Transport Particle B Cartilage Development Involved In Endochondral Bone Morphogenesis Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Non-canonical Wnt Signaling Pathway Spinal Cord Development Endochondral Ossification Keratinocyte Proliferation Neuroepithelial Cell Differentiation Bone Morphogenesis Negative Regulation Of Signal Transduction Maintenance Of Protein Location In Cell Transcription Regulator Inhibitor Activity Anatomical Structure Morphogenesis Maintenance Of Protein Location Protein Sequestering Activity Non-motile Cilium Assembly Ciliary Tip Chondrocyte Differentiation Regulation Of Keratinocyte Proliferation Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Osteoclast Differentiation Protein Localization To Cilium Intraciliary Transport Limb Development Non-canonical Wnt Signaling Pathway Canonical NF-kappaB Signal Transduction Negative Regulation Of Cell Communication
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