BBS10 and GLIPR1

		BBS10	GLIPR1
Description		Bardet-Biedl syndrome 10	GLI pathogenesis related 1
Image		No pdb structure
GO Annotations	Cellular Component	Cilium Cell Projection	Extracellular Region Extracellular Space Plasma Membrane Membrane Azurophil Granule Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding
	Biological Process	Visual Perception Intracellular Protein Localization Response To Light Stimulus Neuronal Action Potential Response To Endoplasmic Reticulum Stress Retinal Cone Cell Differentiation Regulation Of Protein-containing Complex Assembly Negative Regulation Of Neuron Apoptotic Process Photoreceptor Cell Maintenance Photoreceptor Cell Differentiation Chaperone-mediated Protein Complex Assembly Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Cone Retinal Bipolar Cell Differentiation Non-motile Cilium Assembly	Sexual Reproduction
Pathways		BBSome-mediated cargo-targeting to cilium	PPARA activates gene expression Neutrophil degranulation
Drugs			SOT-107
Diseases		Bardet-Biedl syndrome (BBS)
GWAS			Daytime sleep phenotypes ( 27126917) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		12 interacting genes: CSNK1E FRZB HDAC6 MAP3K7 MAPK6 MAPK8IP2 NR4A1 PTK2 RASA1 RGS2 TNFSF11 YAE1	1 interacting genes: LCOR
Entrez ID		79738	11010
HPRD ID		08036	04071
Ensembl ID		ENSG00000179941	ENSG00000139278
Uniprot IDs		Q8TAM1	P48060
PDB IDs			3Q2R 3Q2U
Enriched GO Terms of Interacting Partners?		Signal Complex Assembly JNK Cascade MAPK Cascade JUN Kinase Binding Signal Transduction Regulation Of Intracellular Signal Transduction MAP Kinase Activity Positive Regulation Of Signal Transduction Protein Phosphorylation Phosphorylation Positive Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Cell Growth Response To Amphetamine Regulation Of JNK Cascade Regulation Of Cell Communication Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Signaling Non-canonical Wnt Signaling Pathway Negative Regulation Of Hepatocyte Differentiation Regulation Of Apoptotic Process Negative Regulation Of Growth Protein Kinase Binding Positive Regulation Of Epithelial Cell Migration Ephrin Receptor Signaling Pathway Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Beta-tubulin Binding Response To Amine Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Fc Receptor Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Cell Morphogenesis Cellular Response To Growth Factor Stimulus Kinase Activity Septin Cytoskeleton Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation	Glutamatergic Neuron Differentiation Chaperone-mediated Protein Complex Assembly Retinal Bipolar Neuron Differentiation Retinal Rod Cell Differentiation Cone Retinal Bipolar Cell Differentiation Photoreceptor Cell Differentiation Eye Photoreceptor Cell Differentiation Camera-type Eye Photoreceptor Cell Differentiation Retinal Cone Cell Differentiation Histone Methyltransferase Binding Ubiquitin-specific Protease Binding Neuronal Action Potential Photoreceptor Cell Maintenance Cellular Response To Estradiol Stimulus Nuclear Estrogen Receptor Binding Transcription Corepressor Binding Non-motile Cilium Assembly
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