WDR59 and SESN3

Number of citations of the paper that reports this interaction (PubMedID 25263562)
44

Data Source:
BioGRID (pull down)

		WDR59	SESN3
Description		WD repeat domain 59	sestrin 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Vacuolar Membrane Cytosol Membrane Seh1-associated Complex GATOR2 Complex	Nucleus Cytoplasm TORC2 Complex GATOR2 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Signaling Adaptor Activity Metal Ion Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor L-leucine Binding
	Biological Process	Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Positive Regulation Of Macroautophagy Response To Insulin Cellular Response To Amino Acid Starvation TORC2 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Amino acids regulate mTORC1	TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Pancreatic cancer ( 25086665) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Post bronchodilator FEV1/FVC ratio ( 26634245) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Venous thromboembolism ( 32232851)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		5 interacting genes: DSCAM EP300 FXR2 SESN3 VIM	5 interacting genes: DSCR9 MIOS NPRL3 WDR24 WDR59
Entrez ID		79726	143686
HPRD ID		13351	09682
Ensembl ID		ENSG00000103091	ENSG00000149212
Uniprot IDs		Q6PJI9	P58005
PDB IDs		7UHY
Enriched GO Terms of Interacting Partners?		TORC2 Signaling Cellular Response To L-leucine Response To L-leucine Positive Regulation Of Cell Development Regulation Of Neuron Projection Development TOR Signaling Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Cellular Response To Amino Acid Stimulus Histone Crotonyltransferase Activity Positive Regulation Of Metabolic Process Regulation Of TORC1 Signaling Post-embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Plasma Membrane Bounded Cell Projection Organization Netrin Receptor Binding Regulation Of Cell Projection Organization Response To Amino Acid Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Regulation Of TOR Signaling Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Cell Development Positive Regulation Of Cell Differentiation Cellular Response To Oxygen-containing Compound Negative Regulation Of Protein Oligomerization Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Neurogenesis L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Keratin Filament Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Regulation Of Tubulin Deacetylation L-leucine Binding Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment	Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling GATOR2 Complex Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Positive Regulation Of TORC1 Signaling Lysosomal Membrane Positive Regulation Of TOR Signaling Response To Nutrient Levels Lysosome Vacuolar Membrane Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Oligodendrocyte Progenitor Proliferation Cellular Response To Stress Seh1-associated Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy GATOR1 Complex Central Nervous System Myelin Formation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Myelin Assembly Regulation Of Autophagy Response To Stress Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Aorta Morphogenesis Protein K6-linked Ubiquitination Ventricular Septum Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Catabolic Process Cellular_component Zinc Ion Binding Oligodendrocyte Differentiation Cardiac Septum Development Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation
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