WDR59

Description		WD repeat domain 59
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Vacuolar Membrane Cytosol Membrane Seh1-associated Complex GATOR2 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Signaling Adaptor Activity Metal Ion Binding
	Biological Process	Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Pancreatic cancer ( 25086665) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Post bronchodilator FEV1/FVC ratio ( 26634245) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Venous thromboembolism ( 32232851)
Interacting Genes		5 interacting genes: DSCAM EP300 FXR2 SESN3 VIM
Entrez ID		79726
HPRD ID		13351
Ensembl ID		ENSG00000103091
Uniprot IDs		Q6PJI9
PDB IDs		7UHY
Enriched GO Terms of Interacting Partners?		TORC2 Signaling Cellular Response To L-leucine Response To L-leucine Positive Regulation Of Cell Development Regulation Of Neuron Projection Development TOR Signaling Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Cellular Response To Amino Acid Stimulus Histone Crotonyltransferase Activity Positive Regulation Of Metabolic Process Regulation Of TORC1 Signaling Post-embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Plasma Membrane Bounded Cell Projection Organization Netrin Receptor Binding Regulation Of Cell Projection Organization Response To Amino Acid Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Regulation Of TOR Signaling Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Cell Development Positive Regulation Of Cell Differentiation Cellular Response To Oxygen-containing Compound Negative Regulation Of Protein Oligomerization Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Neurogenesis L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Keratin Filament Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Regulation Of Tubulin Deacetylation L-leucine Binding Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment
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