NLRX1 and BUD13

		NLRX1	BUD13
Description		NLR family member X1	BUD13 spliceosome associated protein
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP RES Complex U2-type Precatalytic Spliceosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	RNA Binding Protein Binding
	Biological Process	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Adventurousness ( 30643258) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Cardiovascular risk factors (age interaction) ( 20838585) Coronary artery disease ( 29263402 29212778) Cutaneous squamous cell carcinoma ( 32041948 27424798) Delirium ( 29631748) Disease progression in age-related macular degeneration ( 29346644) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HIV-1 susceptibility ( 21160409) Hypertriglyceridemia ( 23505323 31087446) LDL cholesterol ( 20864672) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid traits ( 24023261) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Low density lipoprotein cholesterol levels ( 33339817) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolic syndrome ( 21386085 30382898) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23823483 31628463) Platelet count ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Red cell distribution width ( 28957414) Response to Vitamin E supplementation ( 22437554) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Total cholesterol levels ( 33339817) Triglyceride levels ( 30698716 29615537 32902719 32203549 28371326 26763881 30911093) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 20864672 26160806 24886709 18193044 21909109) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)
Interacting Genes		1 interacting genes: SARM1	3 interacting genes: GPKOW RBMX2 SRPK2
Entrez ID		79671	84811
HPRD ID		17640	11307
Ensembl ID		ENSG00000160703	ENSG00000137656
Uniprot IDs		A0A9L9PX86 Q86UT6	Q9BRD0
PDB IDs		3UN9	5Z56 5Z57 5Z58 6FF4 6FF7 7ABI 7DVQ 7QTT 8CH6 8I0P 8I0R
Enriched GO Terms of Interacting Partners?		NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity	RNA Splicing Spliceosomal Complex Assembly MRNA Processing MRNA Metabolic Process RNA Processing Protein-RNA Complex Assembly Nuclear Speck Organization MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions Negative Regulation Of RIG-I Signaling Pathway RNA Metabolic Process R-loop Processing RNA Binding Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Nuclear Body Organization Precatalytic Spliceosome Regulation Of RIG-I Signaling Pathway Nucleic Acid Metabolic Process Nucleic Acid Binding U2-type Prespliceosome Assembly U2 SnRNP
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