NLRX1 and TMPRSS4

		NLRX1	TMPRSS4
Description		NLR family member X1	transmembrane serine protease 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Secretory Granule
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	Proteolysis Response To Wounding Regulation Of Gene Expression Protein Processing Negative Regulation Of Growth Rate Positive Regulation Of Viral Entry Into Host Cell
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)
Interacting Genes		1 interacting genes: SARM1	14 interacting genes: BNIP3L CLEC7A CLRN1 ERVFRD-1 FAM209A FNDC9 GPX8 KASH5 LMNA RASGRP4 SIGLEC12 SUSD3 SYNE4 TMEM79
Entrez ID		79671	56649
HPRD ID		17640	05952
Ensembl ID		ENSG00000160703	ENSG00000137648
Uniprot IDs		A0A9L9PX86 Q86UT6	A0AAQ5BHV4 B7Z458 B7Z8X1 B7Z900 E7ESG9 Q9NRS4
PDB IDs		3UN9
Enriched GO Terms of Interacting Partners?		NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity	Nuclear Envelope Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex
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