NLRX1 and C1QTNF5

		NLRX1	C1QTNF5
Description		NLR family member X1	C1q and TNF related 5
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane	Extracellular Region Collagen Trimer Extracellular Space Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Lateral Plasma Membrane Transport Vesicle Protein-containing Complex Cell Projection
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Protein Binding Identical Protein Binding
	Biological Process	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	Protein Secretion Inner Ear Development
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Blood protein levels ( 30072576) Lifespan ( 25918517)
Interacting Genes		1 interacting genes: SARM1	5 interacting genes: GUCA1A MFRP SGTA SGTB SLC2A4
Entrez ID		79671	114902
HPRD ID		17640	10575
Ensembl ID		ENSG00000160703	ENSG00000223953
Uniprot IDs		A0A9L9PX86 Q86UT6	Q9BXJ0
PDB IDs		3UN9	4F3J 4NN0
Enriched GO Terms of Interacting Partners?		NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity	TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Positive Regulation Of Guanylate Cyclase Activity Protein Targeting To Membrane Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Guanylate Cyclase Regulator Activity Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of CGMP-mediated Signaling Calcium Sensitive Guanylate Cyclase Activator Activity Visual Perception Sensory Perception Of Light Stimulus Nervous System Process Cone Photoreceptor Outer Segment Establishment Of Protein Localization To Membrane Protein Targeting BAT3 Complex Binding Molecular Adaptor Activity Negative Regulation Of ERAD Pathway Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus White Fat Cell Proliferation Negative Regulation Of RIG-I Signaling Pathway Dehydroascorbic Acid Transport Fat Cell Proliferation D-glucose Transmembrane Transporter Activity Membrane Short-term Memory Negative Regulation Of Macrophage Cytokine Production Regulation Of CGMP-mediated Signaling Negative Regulation Of Interferon-beta Production Establishment Of Protein Localization To Organelle Tail-anchored Membrane Protein Insertion Into ER Membrane Trans-Golgi Network Transport Vesicle
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