DYNC2H1 and CARD18

		DYNC2H1	CARD18
Description		dynein cytoplasmic 2 heavy chain 1	caspase recruitment domain family member 18
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Axoneme Membrane Dynein Complex Motile Cilium Cell Projection Apical Part Of Cell Extracellular Exosome Ciliary Tip 9+2 Motile Cilium	Protein-containing Complex
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Cysteine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Peptidase Inhibitor Activity CARD Domain Binding Caspase Binding
	Biological Process	Kidney Development Microtubule-based Movement Golgi Organization Determination Of Left/right Symmetry Heart Development Dorsal/ventral Pattern Formation Protein Processing Spinal Cord Motor Neuron Differentiation Central Nervous System Neuron Differentiation Cell Projection Organization Neuron Differentiation Embryonic Limb Morphogenesis Forebrain Development Intraciliary Retrograde Transport Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Cilium Movement Involved In Cell Motility Coronary Vasculature Development Protein Localization To Cilium Non-motile Cilium Assembly	Proteolysis Inflammatory Response Negative Regulation Of Protein Binding Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process
Pathways		Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases		Asphyxiating thoracic dystrophy; Jeune syndrome Short rib-polydactyly syndrome
GWAS		Adult body size ( 32376654) Coronary artery disease ( 32469254 33020668) Diisocyanate-induced asthma ( 25918132) Response to lurasidone in schizophrenia ( 29730043) Small-cell lung cancer (survival) ( 21118971) Spine bone mineral density and alcohol drinking ( 28012008) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)
Interacting Genes		4 interacting genes: DYNC2LI1 MTNR1B PAXIP1 RNF10	2 interacting genes: CARD17P CARD8
Entrez ID		79659	59082
HPRD ID		10344	16099
Ensembl ID		ENSG00000187240	ENSG00000255501
Uniprot IDs		Q8NCM8	P57730
PDB IDs		4RH7 8RGG 8RGH	1DGN
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production CARD8 Inflammasome Complex NACHT Domain Binding Proteolysis CARD8 Inflammasome Complex Assembly Protein Maturation Negative Regulation Of Cytokine Production NLRP3 Inflammasome Complex Negative Regulation Of NLRP3 Inflammasome Complex Assembly Self Proteolysis Canonical Inflammasome Complex Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway CARD Domain Binding Pyroptotic Cell Death Cysteine-type Endopeptidase Activator Activity Intraciliary Retrograde Transport Minus-end-directed Microtubule Motor Activity Caspase Binding Cytoplasmic Dynein Complex Spinal Cord Motor Neuron Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Canonical Inflammasome Complex Assembly Protein-containing Complex Protein Metabolic Process Dynein Intermediate Chain Binding 9+2 Motile Cilium Dynein Light Intermediate Chain Binding Dynein Complex Coronary Vasculature Development Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Cytokine Production Pattern Recognition Receptor Activity Cell Differentiation In Spinal Cord Positive Regulation Of Smoothened Signaling Pathway Pyroptotic Inflammatory Response Regulation Of NLRP3 Inflammasome Complex Assembly Ciliary Tip Intraciliary Transport Molecular Condensate Scaffold Activity
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