DYNC2H1 and ANGPTL5

		DYNC2H1	ANGPTL5
Description		dynein cytoplasmic 2 heavy chain 1	angiopoietin like 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Axoneme Membrane Dynein Complex Motile Cilium Cell Projection Apical Part Of Cell Extracellular Exosome Ciliary Tip 9+2 Motile Cilium	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding
	Biological Process	Kidney Development Microtubule-based Movement Golgi Organization Determination Of Left/right Symmetry Heart Development Dorsal/ventral Pattern Formation Protein Processing Spinal Cord Motor Neuron Differentiation Central Nervous System Neuron Differentiation Cell Projection Organization Neuron Differentiation Embryonic Limb Morphogenesis Forebrain Development Intraciliary Retrograde Transport Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Cilium Movement Involved In Cell Motility Coronary Vasculature Development Protein Localization To Cilium Non-motile Cilium Assembly
Pathways		Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases		Asphyxiating thoracic dystrophy; Jeune syndrome Short rib-polydactyly syndrome
GWAS		Adult body size ( 32376654) Coronary artery disease ( 32469254 33020668) Diisocyanate-induced asthma ( 25918132) Response to lurasidone in schizophrenia ( 29730043) Small-cell lung cancer (survival) ( 21118971) Spine bone mineral density and alcohol drinking ( 28012008) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)	Daytime nap ( 33568662) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Systemic sclerosis ( 29293537)
Interacting Genes		4 interacting genes: DYNC2LI1 MTNR1B PAXIP1 RNF10
Entrez ID		79659	253935
HPRD ID		10344	09638
Ensembl ID		ENSG00000187240	ENSG00000187151
Uniprot IDs		Q8NCM8	Q86XS5
PDB IDs		4RH7 8RGG 8RGH
Enriched GO Terms of Interacting Partners?			Non-motile Cilium Assembly Cytoplasmic Dynein Complex Ciliary Tip Dynein Intermediate Chain Binding Cell Differentiation In Spinal Cord Intraciliary Retrograde Transport 9+2 Motile Cilium Minus-end-directed Microtubule Motor Activity Dynein Light Intermediate Chain Binding Cytoskeletal Motor Activity Dynein Complex Intraciliary Transport Spinal Cord Motor Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Dorsal/ventral Pattern Formation Determination Of Bilateral Symmetry Forebrain Development Embryonic Limb Morphogenesis Regulation Of Smoothened Signaling Pathway Apical Part Of Cell Determination Of Left/right Symmetry Protein Localization To Cilium Limb Morphogenesis Golgi Organization Axoneme Cilium Movement Involved In Cell Motility Central Nervous System Neuron Differentiation Blood Vessel Development Kidney Development Cilium Movement Transport Along Microtubule Protein Processing Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Motile Cilium Heart Development Cilium Assembly Regionalization Cilium Organization Protein Maturation Microtubule Neuron Differentiation Cell Projection Assembly Plasma Membrane Bounded Cell Projection Assembly Microtubule-based Movement
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