SRD5A3 and NUDT15

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SRD5A3	NUDT15
Gene Name		steroid 5 alpha-reductase 3	nudix (nucleoside diphosphate linked moiety X)-type motif 15
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Cholestenone 5-alpha-reductase Activity	8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Metal Ion Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Androgen Biosynthetic Process Steroid Metabolic Process Polyprenol Catabolic Process Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	DGTP Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Androgen biosynthesis Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Synthesis of Dolichyl-phosphate Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Metabolism of steroid hormones and vitamin D Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins	Phosphate bond hydrolysis by NUDT proteins Metabolism of nucleotides
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ADK NUDT15	1 interactors: SRD5A3
Entrez ID		79644	55270
HPRD ID		07825	14848
Ensembl ID		ENSG00000128039	ENSG00000136159
Uniprot IDs		Q9H8P0	Q9NV35
PDB IDs
Enriched GO Terms of Interacting Partners?		Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Metabolic Process DATP Biosynthetic Process AMP Salvage Purine Nucleotide Metabolic Process DGTP Catabolic Process DGTP Metabolic Process Nucleobase-containing Small Molecule Catabolic Process AMP Biosynthetic Process Purine Ribonucleoside Salvage Nucleotide Metabolic Process Deoxyribonucleoside Triphosphate Catabolic Process DATP Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nucleoside Triphosphate Catabolic Process Type B Pancreatic Cell Proliferation Adenosine Metabolic Process Deoxyribonucleotide Biosynthetic Process AMP Metabolic Process Purine Nucleotide Salvage Deoxyribose Phosphate Catabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Organophosphate Metabolic Process Purine-containing Compound Salvage Deoxyribonucleotide Catabolic Process Regulation Of Cardiac Muscle Hypertrophy Purine Nucleotide Catabolic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Nucleotide Catabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of T Cell Proliferation Nucleoside Triphosphate Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Small Molecule Metabolic Process Regulation Of T Cell Proliferation Organophosphate Catabolic Process Purine Nucleotide Biosynthetic Process Circadian Rhythm Ribose Phosphate Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Purine Nucleoside Metabolic Process Regulation Of T Cell Activation Ribonucleotide Metabolic Process	Polyprenol Catabolic Process Dolichol Metabolic Process Dolichyl Diphosphate Biosynthetic Process Androgen Biosynthetic Process Androgen Metabolic Process Alcohol Catabolic Process Hormone Biosynthetic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Steroid Biosynthetic Process Protein N-linked Glycosylation Isoprenoid Metabolic Process Cellular Lipid Catabolic Process Hormone Metabolic Process Post-translational Protein Modification Phospholipid Biosynthetic Process Lipid Catabolic Process Steroid Metabolic Process Regulation Of Hormone Levels Macromolecule Glycosylation Protein Glycosylation Alcohol Metabolic Process Glycosylation Phospholipid Metabolic Process Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Lipid Biosynthetic Process
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