NUDT15

Description		nudix hydrolase 15
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Hydrolase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity 8-oxo-dGDP Phosphatase Activity Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity
	Biological Process	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Response To Stress Purine Deoxyribonucleoside Triphosphate Catabolic Process Xenobiotic Catabolic Process DNA Protection Nucleobase-containing Small Molecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process
Pathways		Phosphate bond hydrolysis by NUDT proteins Azathioprine ADME
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Novel Interacting Genes		4 novel interacting genes: CDADC1 FNDC3A MTRF1 UTP14C
Interacting Genes		2 interacting genes: GABARAPL2 SRD5A3
Entrez ID		55270
HPRD ID		14848
Ensembl ID		ENSG00000136159
Uniprot IDs		Q9NV35
PDB IDs		5BON 5LPG 6T5J 7AOM 7AOP 7B63 7B64 7B65 7B66 7B67 7B7V 7NR6 7R0D
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Disassembly Translation Release Factor Activity, Codon Specific Mitochondrial Translational Termination Polyprenol Reductase Activity 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity 3-oxo-5-alpha-steroid 4-dehydrogenase Activity Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Polyprenal Reductase Activity DCMP Deaminase Activity Translation Release Factor Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Androgen Biosynthetic Process DNA Cytosine Deamination Translational Termination Cellular Response To Nitrogen Starvation Importin-alpha Family Protein Binding Cytidine Deaminase Activity DNA Deamination Phosphatidylethanolamine Binding Protein Localization To Endoplasmic Reticulum GABA Receptor Binding Sertoli Cell Development Dolichol-linked Oligosaccharide Biosynthetic Process Positive Regulation Of ATP-dependent Activity
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