GALNT14 and MUC5AC

Number of citations of the paper that reports this interaction (PubMedID 12507512)
0

Data Source:
BioGRID (enzymatic study)

		GALNT14	MUC5AC
Description		polypeptide N-acetylgalactosaminyltransferase 14	mucin 5AC, oligomeric mucus/gel-forming
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Extracellular Region Extracellular Space Golgi Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome Mucus Layer
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Metal Ion Binding
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine
Pathways		O-linked glycosylation of mucins	Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs
Diseases
GWAS		Eye movement (horizontal position gain) ( 30120336) HIV-1 viral setpoint ( 22174851) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Oropharynx cancer ( 32276964) Type 2 diabetes ( 25102180) Vaginal microbiome composition (L. iners) ( 32723796)	Asthma ( 31959851 34103634) Asthma (adult onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		4 interacting genes: MUC13 MUC2 MUC5AC MUC7	2 interacting genes: GALNT12 GALNT14
Entrez ID		79623	4586
HPRD ID		12194
Ensembl ID		ENSG00000158089	ENSG00000215182
Uniprot IDs		B7Z5C5 Q96FL9	P98088
PDB IDs			5AJN 5AJO 5AJP 8OV0 8QSP 8QTB 8QTV 8R1U 8R1Z 8UI6 8UJF 8V9Q 9GVJ 9GVQ
Enriched GO Terms of Interacting Partners?		Golgi Lumen Maintenance Of Gastrointestinal Epithelium Epithelial Structure Maintenance Digestive System Process Extracellular Region Outer Mucus Layer Inner Mucus Layer Mucus Layer Anatomical Structure Homeostasis Tissue Homeostasis Cupric Ion Binding Cuprous Ion Binding Host-mediated Modulation Of Intestinal Microbiota Composition Detoxification Of Copper Ion Extracellular Matrix Mucus Secretion Multicellular Organismal-level Homeostasis Plasma Membrane	Polypeptide N-acetylgalactosaminyltransferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Protein O-linked Glycosylation Protein Glycosylation Glycosylation Macromolecule Glycosylation Carbohydrate Binding Glycosyltransferase Activity Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Carbohydrate Derivative Biosynthetic Process Golgi Membrane Carbohydrate Derivative Metabolic Process Golgi Apparatus Macromolecule Biosynthetic Process Protein Modification Process Transferase Activity Protein Metabolic Process
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