GALNT14 and MUC2

Number of citations of the paper that reports this interaction (PubMedID 12507512)
0

Data Source:
HPRD (in vitro)

		GALNT14	MUC2
Description		polypeptide N-acetylgalactosaminyltransferase 14	mucin 2, oligomeric mucus/gel-forming
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Extracellular Region Golgi Lumen Plasma Membrane Extracellular Matrix Inner Mucus Layer Outer Mucus Layer
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding	Protein Binding Cupric Ion Binding Cuprous Ion Binding
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine	Detoxification Of Copper Ion Maintenance Of Gastrointestinal Epithelium Host-mediated Modulation Of Intestinal Microbiota Composition Mucus Secretion
Pathways		O-linked glycosylation of mucins	Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs			Pranlukast Colforsin
Diseases
GWAS		Eye movement (horizontal position gain) ( 30120336) HIV-1 viral setpoint ( 22174851) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Oropharynx cancer ( 32276964) Type 2 diabetes ( 25102180) Vaginal microbiome composition (L. iners) ( 32723796)	Asthma ( 30929738 31361310 31959851 32296059 34103634) Asthma (adult onset) ( 30929738) Interstitial lung disease ( 23583980) Medication use (adrenergics, inhalants) ( 31015401)
Interacting Genes		4 interacting genes: MUC13 MUC2 MUC5AC MUC7	4 interacting genes: GALNT12 GALNT14 MLH1 PLEKHM1
Entrez ID		79623	4583
HPRD ID		12194	11828
Ensembl ID		ENSG00000158089	ENSG00000198788
Uniprot IDs		B7Z5C5 Q96FL9	A0A3S8TMF2 Q02817
PDB IDs			6RBF 6TM2 6TM6 7A5O 7POV 7PP6 7PRL 7QCL 7QCN 7QCU 8CK2 8S03
Enriched GO Terms of Interacting Partners?		Golgi Lumen Maintenance Of Gastrointestinal Epithelium Epithelial Structure Maintenance Digestive System Process Extracellular Region Outer Mucus Layer Inner Mucus Layer Mucus Layer Anatomical Structure Homeostasis Tissue Homeostasis Cupric Ion Binding Cuprous Ion Binding Host-mediated Modulation Of Intestinal Microbiota Composition Detoxification Of Copper Ion Extracellular Matrix Mucus Secretion Multicellular Organismal-level Homeostasis Plasma Membrane	Telomere Localization Polypeptide N-acetylgalactosaminyltransferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Organelle Localization Chromosome Localization Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Telomere Tethering At Nuclear Periphery Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Protein O-linked Glycosylation Protein Glycosylation Glycosylation Macromolecule Glycosylation Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Nuclear Pore Cytoplasmic Filaments Carbohydrate Binding Glycosyltransferase Activity Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Glycoprotein Biosynthetic Process Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Autolysosome Membrane Glycoprotein Metabolic Process Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Spindle Midzone Assembly Chromosome Organization Somatic Diversification Of Immune Receptors Via Somatic Mutation Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Nuclear Pore Nuclear Basket Nuclear Inclusion Body Nuclear Pore Organization Positive Regulation Of Ruffle Assembly Autolysosome Autophagosome-lysosome Fusion
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