TRPM8 and TRIM4

Number of citations of the paper that reports this interaction (PubMedID 33037615)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TRPM8	TRIM4
Description		transient receptor potential cation channel subfamily M member 8	tripartite motif containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Plasma Membrane Raft Membrane Raft	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Identical Protein Binding Metal Ion Binding Metal Ion Transmembrane Transporter Activity Ligand-gated Calcium Channel Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Response To Temperature Stimulus Response To Cold Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Thermoception Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cold-induced Thermogenesis	Immune System Process Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response
Pathways		TRP channels	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Levomenthol Camphor Cannabidiol (S)-camphor Tetrahydrocannabivarin Medical Cannabis Nabiximols Menthol
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 31319653) Blood pressure measurement (cold pressor test) ( 24165912) Hair greying ( 26926045) Headache ( 29397368) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 21666692 27182965 27322543 23793025 22683712) Migraine - clinic-based ( 23793025) Migraine with aura ( 23793025) Migraine without aura ( 23793025 27322543)	Dehydroepiandrosterone sulphate levels ( 21533175) Estrone levels ( 29325096) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum metabolite levels ( 23093944) Tacrolimus trough concentration in kidney transplant patients ( 29160300)
Interacting Genes		1 interacting genes: TRIM4	4 interacting genes: CEBPA MDM2 TRIM41 TRPM8
Entrez ID		79054	89122
HPRD ID		09454	15556
Ensembl ID		ENSG00000144481	ENSG00000146833
Uniprot IDs		A0A0C4DFT0 A0A1L1Z822 A0A1L1Z836 A0A1L1Z853 A0A1L1Z856 A0A1L1Z857 A0A1L1Z860 A0A1L1Z866 A0A1L1Z878 Q7Z2W7 W8DTH1	Q9C037
PDB IDs		8BDC
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Proteolysis Nucleolus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Intracellular Signaling Cassette Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Lipid Intracellular Signal Transduction Response To Vitamin RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Nutrient Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Identical Protein Binding Response To Steroid Hormone Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Vitamin B1 NEDD8 Ligase Activity Response To Actinomycin D Response To Water-immersion Restraint Stress Response To Formaldehyde Cellular Response To Vitamin B1 Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To UV-C Cellular Response To Actinomycin D Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Nuclear Speck Organization Ligand-gated Calcium Channel Activity Thermoception Protein Domain Specific Binding Receptor Serine/threonine Kinase Binding Response To Phenylpropanoid Regulation Of Cell Cycle Fat Cell Proliferation Sensory Perception Of Temperature Stimulus Atrial Septum Development Fibroblast Activation R-loop Processing Response To Xenobiotic Stimulus Peroxisome Proliferator Activated Receptor Binding Cellular Response To Antibiotic
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