TRIM4

Description		tripartite motif containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175) Estrone levels ( 29325096) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum metabolite levels ( 23093944) Tacrolimus trough concentration in kidney transplant patients ( 29160300)
Novel Interacting Genes		1 novel interacting genes: SRPK2
Interacting Genes		4 interacting genes: CEBPA MDM2 TRIM41 TRPM8
Entrez ID		89122
HPRD ID		15556
Ensembl ID		ENSG00000146833
Uniprot IDs		Q9C037
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Nucleolus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Intracellular Signaling Cassette Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Lipid Intracellular Signal Transduction Response To Vitamin RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Nutrient Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Identical Protein Binding Response To Steroid Hormone Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Vitamin B1 NEDD8 Ligase Activity Response To Actinomycin D Response To Water-immersion Restraint Stress Response To Formaldehyde Cellular Response To Vitamin B1 Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To UV-C Cellular Response To Actinomycin D Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Nuclear Speck Organization Ligand-gated Calcium Channel Activity Thermoception Protein Domain Specific Binding Receptor Serine/threonine Kinase Binding Response To Phenylpropanoid Regulation Of Cell Cycle Fat Cell Proliferation Sensory Perception Of Temperature Stimulus Atrial Septum Development Fibroblast Activation R-loop Processing Response To Xenobiotic Stimulus Peroxisome Proliferator Activated Receptor Binding Cellular Response To Antibiotic
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