ZNF229 and ATP1A3

Data Source: HiPPIP (Novel)

		ZNF229	ATP1A3
Name		zinc finger protein 229	ATPase Na+/K+ transporting subunit alpha 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Axon Organelle Membrane Neuronal Cell Body Membrane Neuronal Cell Body Synapse Photoreceptor Inner Segment Membrane Neuron To Neuron Synapse Extracellular Vesicle
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Amyloid-beta Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity ATP Hydrolysis Activity Metal Ion Binding Protein-folding Chaperone Binding Steroid Hormone Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Resting Membrane Potential Cellular Response To Steroid Hormone Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Cellular Response To Amyloid-beta Neuron Projection Maintenance Potassium Ion Import Across Plasma Membrane
Pathways		None	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		None	Ouabain Bisacodyl Tegoprazan
Diseases		None	Primary torsion dystonia (PTD)
GWAS		Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Metabolite levels ( 23823483 )	Brain morphology (MOSTest) ( 32665545 ) Meat-related diet ( 32066663 )
Novel Interactors		1 novel interactors: ATP1A3	9 novel interactors: ABCA4 ASH2L ATRX DUSP4 LYPD3 PPFIA3 PRKD2 TRIM29 ZNF229
Interacting Genes		2 interacting genes: CABP5 TPM2	2 interacting genes: ATXN1 CASP8
Entrez ID		7772	478
HPRD ID		18324	01666
Ensembl ID		ENSG00000278318	ENSG00000105409
Uniprot IDs		A0A087WVZ7 Q9UJW7	M0R116 P13637 Q53ES0
PDB IDs		Not available	8D3U 8D3V 8D3W 8D3X 8D3Y
GO Terms Enriched among Interactors		P-type Sodium:potassium-exchanging Transporter Activity Response To Glycoside Photoreceptor Inner Segment Membrane Steroid Hormone Binding Neuron To Neuron Synapse P-type Potassium Transmembrane Transporter Activity Muscle Thin Filament Tropomyosin Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Sodium:potassium-exchanging ATPase Complex Neuron Projection Maintenance Regulation Of Resting Membrane Potential Sodium Ion Export Across Plasma Membrane Cell Communication By Electrical Coupling Involved In Cardiac Conduction Intracellular Potassium Ion Homeostasis Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Intracellular Sodium Ion Homeostasis Neuronal Cell Body Membrane Regulation Of ATP-dependent Activity Sodium Ion Homeostasis Potassium Ion Homeostasis Neuron Projection Organization Potassium Ion Import Across Plasma Membrane Organelle Membrane Structural Constituent Of Muscle Calcium Channel Regulator Activity Cellular Response To Amyloid-beta Export Across Plasma Membrane Response To Amyloid-beta Photoreceptor Inner Segment	None