ATP1A3 and ZNF229

Data Source: HiPPIP (Novel)

		ATP1A3	ZNF229
Name		ATPase Na+/K+ transporting subunit alpha 3	zinc finger protein 229
Structure			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Axon Organelle Membrane Neuronal Cell Body Membrane Neuronal Cell Body Synapse Photoreceptor Inner Segment Membrane Neuron To Neuron Synapse Extracellular Vesicle	Nucleus
	Molecular Function	Nucleotide Binding Amyloid-beta Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity ATP Hydrolysis Activity Metal Ion Binding Protein-folding Chaperone Binding Steroid Hormone Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Resting Membrane Potential Cellular Response To Steroid Hormone Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Cellular Response To Amyloid-beta Neuron Projection Maintenance Potassium Ion Import Across Plasma Membrane	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	None
Drugs		Ouabain Bisacodyl Tegoprazan	None
Diseases		Primary torsion dystonia (PTD)	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Meat-related diet ( 32066663 )	Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Metabolite levels ( 23823483 )
Novel Interactors		9 novel interactors: ABCA4 ASH2L ATRX DUSP4 LYPD3 PPFIA3 PRKD2 TRIM29 ZNF229	1 novel interactors: ATP1A3
Interacting Genes		2 interacting genes: ATXN1 CASP8	2 interacting genes: CABP5 TPM2
Entrez ID		478	7772
HPRD ID		01666	18324
Ensembl ID		ENSG00000105409	ENSG00000278318
Uniprot IDs		M0R116 P13637 Q53ES0	A0A087WVZ7 Q9UJW7
PDB IDs		8D3U 8D3V 8D3W 8D3X 8D3Y	Not available
GO Terms Enriched among Interactors		None	P-type Sodium:potassium-exchanging Transporter Activity Response To Glycoside Photoreceptor Inner Segment Membrane Steroid Hormone Binding Neuron To Neuron Synapse P-type Potassium Transmembrane Transporter Activity Muscle Thin Filament Tropomyosin Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Sodium:potassium-exchanging ATPase Complex Neuron Projection Maintenance Regulation Of Resting Membrane Potential Sodium Ion Export Across Plasma Membrane Cell Communication By Electrical Coupling Involved In Cardiac Conduction Intracellular Potassium Ion Homeostasis Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Intracellular Sodium Ion Homeostasis Neuronal Cell Body Membrane Regulation Of ATP-dependent Activity Sodium Ion Homeostasis Potassium Ion Homeostasis Neuron Projection Organization Potassium Ion Import Across Plasma Membrane Organelle Membrane Structural Constituent Of Muscle Calcium Channel Regulator Activity Cellular Response To Amyloid-beta Export Across Plasma Membrane Response To Amyloid-beta Photoreceptor Inner Segment