EIF4H and CCL24

		EIF4H	CCL24
Description		eukaryotic translation initiation factor 4H	C-C motif chemokine ligand 24
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding Cadherin Binding	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Sexual Reproduction Developmental Growth Eukaryotic Translation Initiation Factor 4F Complex Assembly	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Positive Regulation Of Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Eosinophil Migration
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			CCL24 levels ( 25147954) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sarcoidosis ( 32826979) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		8 interacting genes: C11orf68 CEBPA DDIT4L DLG3 FBXO17 LNX1 PICK1 SPG21	6 interacting genes: CCL13 CCL21 CCL5 CCR3 CXCL11 XCL1
Entrez ID		7458	6369
HPRD ID		11940	03931
Ensembl ID		ENSG00000106682	ENSG00000106178
Uniprot IDs		Q15056	O00175
PDB IDs			1EIG 1EIH
Enriched GO Terms of Interacting Partners?			Chemokine-mediated Signaling Pathway Chemokine Activity Cytokine-mediated Signaling Pathway Cell Chemotaxis CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Leukocyte Chemotaxis Antimicrobial Humoral Response Chemokine Receptor Binding Cytokine Activity Inflammatory Response Granulocyte Chemotaxis Positive Regulation Of T Cell Chemotaxis Leukocyte Migration Regulation Of T Cell Chemotaxis Humoral Immune Response Granulocyte Migration Positive Regulation Of Lymphocyte Chemotaxis Eosinophil Chemotaxis Eosinophil Migration Mononuclear Cell Migration Regulation Of Lymphocyte Chemotaxis Killing Of Cells Of Another Organism Myeloid Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Positive Regulation Of T Cell Migration Cell Migration Positive Regulation Of Lymphocyte Migration Cell Killing Regulation Of T Cell Migration Cell Motility Regulation Of Granulocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Cell Surface Receptor Signaling Pathway Immune Response Cell-cell Signaling Regulation Of Lymphocyte Migration Signaling Cell Communication Defense Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Transport Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Cellular Response To Cytokine Stimulus
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