TPSAB1 and ADAMTS1

		TPSAB1	ADAMTS1
Description		tryptase alpha/beta 1	ADAM metallopeptidase with thrombospondin type 1 motif 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Matrix Cytoplasmic Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding	Metalloendopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Defense Response Extracellular Matrix Disassembly	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Activation of Matrix Metalloproteinases	Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs		1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine 1-[1'-(3-phenylacryloyl)spiro[1-benzofuran-3,4'-piperidin]-5-yl]methanamine
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)
Interacting Genes			9 interacting genes: A2M ACAN CFTR DYRK1A FURIN KRT40 KRTAP10-8 VCAN VEGFA
Entrez ID		7177	9510
HPRD ID		01849	05530
Ensembl ID		ENSG00000172236	ENSG00000154734
Uniprot IDs		Q15661	B2RB33 Q9UHI8
PDB IDs		1LTO 2F9N 2F9O 2F9P 2ZEB 2ZEC 4A6L 4MPU 4MPV 4MPW 4MPX 4MQA 5F03 5WI6 6O1F 6P0P 6VVU 8VGH 8VGI 8VGJ 8VGK	2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?		Axonal Growth Cone Chaperone-mediated Protein Complex Assembly Dynein Axonemal Particle Protein Phosphatase Activator Activity ATP-dependent Protein Binding HSP90-CDC37 Chaperone Complex Protein Kinase Regulator Activity Histone Methyltransferase Binding RNA-templated DNA Biosynthetic Process Adhesion Of Symbiont To Host Nitric-oxide Synthase Regulator Activity MHC Class II Protein Complex Binding Adhesion Of Symbiont To Host Cell Telomere Maintenance Via Telomerase Dendritic Growth Cone TPR Domain Binding Receptor Ligand Inhibitor Activity Cellular Response To Interleukin-4 Aryl Hydrocarbon Receptor Complex Disordered Domain Specific Binding Virion Attachment To Host Cell DNA Polymerase Binding Positive Regulation Of Protein Localization To Cell Surface Telomerase Holoenzyme Complex Assembly Ovulation From Ovarian Follicle Ovulation Heart Trabecula Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Telomere Maintenance Via Telomere Lengthening Response To Interleukin-4 Peptide Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Folding Chaperone Complex Regulation Of Cell Cycle COP9 Signalosome ATP-dependent Protein Folding Chaperone Regulation Of Protein Localization To Cell Surface Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Ovulation Cycle Process Positive Regulation Of Smooth Muscle Cell Migration Tau Protein Binding Placenta Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Heat Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Folding Chaperone	Extracellular Matrix Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Golgi Lumen Hyaluronic Acid Binding Platelet Alpha Granule Lumen Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Serine-type Endopeptidase Inhibitor Activity Extracellular Space Cell Surface Alpha2-adrenergic Receptor Activity Lysosomal Lumen Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Interphotoreceptor Matrix Histone H3T45 Kinase Activity Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Extracellular Matrix Disassembly Nerve Growth Factor Production Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Neurotrophin Production Lymph Vessel Morphogenesis Negative Regulation Of Adherens Junction Organization VEGF-A Complex Granulocyte Chemotaxis VEGF-activated Neuropilin Signaling Pathway Vascular Endothelial Growth Factor Receptor 1 Binding Negative Regulation Of Blood-brain Barrier Permeability Granulocyte Migration Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Establishment Of Endothelial Barrier Cardiac Vascular Smooth Muscle Cell Development Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Cellular Stress Response To Acid Chemical Coronary Vein Morphogenesis Basophil Chemotaxis Keratin Filament Extracellular Region Protease Binding Positive Regulation Of Enamel Mineralization
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