TPSAB1

Description		tryptase alpha/beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Proteolysis Defense Response Extracellular Matrix Disassembly
Pathways		Activation of Matrix Metalloproteinases
Drugs		1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine 1-[1'-(3-phenylacryloyl)spiro[1-benzofuran-3,4'-piperidin]-5-yl]methanamine
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576)
Novel Interacting Genes		2 novel interacting genes: ADAMTS1 HSP90AB1
Interacting Genes
Entrez ID		7177
HPRD ID		01849
Ensembl ID		ENSG00000172236
Uniprot IDs		Q15661
PDB IDs		1LTO 2F9N 2F9O 2F9P 2ZEB 2ZEC 4A6L 4MPU 4MPV 4MPW 4MPX 4MQA 5F03 5WI6 6O1F 6P0P 6VVU 8VGH 8VGI 8VGJ 8VGK
Enriched GO Terms of Interacting Partners?		Axonal Growth Cone Chaperone-mediated Protein Complex Assembly Dynein Axonemal Particle Protein Phosphatase Activator Activity ATP-dependent Protein Binding HSP90-CDC37 Chaperone Complex Protein Kinase Regulator Activity Histone Methyltransferase Binding RNA-templated DNA Biosynthetic Process Adhesion Of Symbiont To Host Nitric-oxide Synthase Regulator Activity MHC Class II Protein Complex Binding Adhesion Of Symbiont To Host Cell Telomere Maintenance Via Telomerase Dendritic Growth Cone TPR Domain Binding Receptor Ligand Inhibitor Activity Cellular Response To Interleukin-4 Aryl Hydrocarbon Receptor Complex Disordered Domain Specific Binding Virion Attachment To Host Cell DNA Polymerase Binding Positive Regulation Of Protein Localization To Cell Surface Telomerase Holoenzyme Complex Assembly Ovulation From Ovarian Follicle Ovulation Heart Trabecula Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Telomere Maintenance Via Telomere Lengthening Response To Interleukin-4 Peptide Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Folding Chaperone Complex Regulation Of Cell Cycle COP9 Signalosome ATP-dependent Protein Folding Chaperone Regulation Of Protein Localization To Cell Surface Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Ovulation Cycle Process Positive Regulation Of Smooth Muscle Cell Migration Tau Protein Binding Placenta Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Heat Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Folding Chaperone
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