TGIF1 and MOB3A

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		TGIF1	MOB3A
Description		TGFB induced factor homeobox 1	MOB kinase activator 3A
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Co-SMAD Binding Sequence-specific Double-stranded DNA Binding	Protein Kinase Activator Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Regulation Of DNA-templated Transcription Determination Of Left/right Symmetry Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Dorsal/ventral Pattern Formation Regulation Of Gastrulation Negative Regulation Of Gene Expression Neuron Differentiation Amacrine Cell Differentiation Nodal Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Retina Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Positive Regulation Of Amacrine Cell Differentiation	Signal Transduction
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Drugs
Diseases		Holoprosencephaly (HPE)
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Periodontitis (DPAL) ( 24024966) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		22 interacting genes: A2M APP AR CTBP1 CTBP2 DRD1 EEF1A1 HDAC1 HMGB1 IRF2BP1 JUN LRIF1 MAPK1 MAPK3 MDFI MED31 MOB3A PML SIN3A SMAD2 SMAD3 WWP1	7 interacting genes: APP FBXO7 LATS1 LATS2 NEDD4 NEDD4L TGIF1
Entrez ID		7050	126308
HPRD ID		04023	17583
Ensembl ID		ENSG00000177426	ENSG00000172081
Uniprot IDs		Q15583	Q96BX8
PDB IDs		2LK2 6FQP 6FQQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Repressor Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process Nucleus Regulation Of Transcription By RNA Polymerase II SMAD Protein Signal Transduction Regulation Of Metabolic Process Chromatin Binding Cell Differentiation Response To Growth Factor Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Transcription Corepressor Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Transcription Corepressor Binding Positive Regulation Of Intracellular Signal Transduction Phosphatase Binding Developmental Process Positive Regulation Of Chemotaxis Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction Glial Cell Development Regulation Of Intracellular Signal Transduction Cellular Response To Catecholamine Stimulus Regulation Of Cell Migration Negative Regulation Of Cell Population Proliferation Response To Catecholamine	Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Protein Localization Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Developmental Process Negative Regulation Of Signal Transduction Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Synapse Organization Regulation Of Developmental Growth Sodium Channel Inhibitor Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Potassium Channel Inhibitor Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus Receptor Catabolic Process Positive Regulation Of Hippo Signaling Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Catabolic Process Regulation Of Growth Hippo Signaling Regulation Of Cellular Component Organization Positive Regulation Of Protein Catabolic Process Negative Regulation Of Potassium Ion Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Protein Metabolic Process Neuromuscular Junction Development Regulation Of Canonical Wnt Signaling Pathway Synapse Organization Ubiquitin-protein Transferase Activity Regulation Of Monoatomic Cation Transmembrane Transport Cellular Developmental Process Protein Modification Process Protein Metabolic Process Protein Polyubiquitination Regulation Of Hippo Signaling Receptor Metabolic Process Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Monoatomic Ion Transmembrane Transport
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