CYP4F12 and SLC44A2

		CYP4F12	SLC44A2
Description		cytochrome P450 family 4 subfamily F member 12	solute carrier family 44 member 2 (CTL2 blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Outer Membrane Lysosomal Membrane Plasma Membrane Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding Leukotriene-B4 20-monooxygenase Activity	Choline Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Ethanolamine Transmembrane Transporter Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Sodium Ion Homeostasis	Phosphatidylcholine Biosynthetic Process Choline Transport Ethanolamine Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Transmembrane Transport
Pathways		Fatty acids Eicosanoids	Synthesis of PC Neutrophil degranulation SLC-mediated bile acid transport
Drugs
Diseases
GWAS		Glioma ( 34319593) LDL cholesterol levels ( 32203549)	Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 24076602) Platelet count ( 29403010 32888494) Platelet distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Thrombosis ( 26908601) Venous thromboembolism ( 31676865 25772935)
Interacting Genes		5 interacting genes: CFTR HSPA6 MEOX2 SOD2 TIMMDC1	2 interacting genes: BDKRB1 HTR2B
Entrez ID		66002	57153
HPRD ID		07102	16198
Ensembl ID		ENSG00000186204	ENSG00000129353
Uniprot IDs		Q9HCS2	A0A088QCU6 Q8IWA5
PDB IDs
Enriched GO Terms of Interacting Partners?		Enzyme Binding Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Organic Hydroxy Compound Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Somite Specification Response To Magnetism Regulation Of Membrane Hyperpolarization Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Isolation Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Detection Of Oxygen Negative Regulation Of Membrane Hyperpolarization Superoxide Dismutase Activity Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Response To Silicon Dioxide Response To L-ascorbic Acid Ethanolamine Transport Ethanolamine Transmembrane Transporter Activity Positive Regulation Of Tooth Mineralization Cellular Heat Acclimation Response To Superoxide Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Oxygen Radical Choline Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Choline Transport Response To Alcohol ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Intracellular Oxygen Homeostasis Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Response To Selenium Ion Amine Transport Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Response To Manganese Ion	Phylloquinone Catabolic Process Menaquinone Metabolic Process Menaquinone Catabolic Process Vitamin K Catabolic Process Vitamin K Metabolic Process Ketone Catabolic Process Vitamin Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Regulation Of Biological Quality Arachidonate Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Ketone Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Icosanoid Metabolic Process Bradykinin Receptor Activity Oxylipin Biosynthetic Process Iron Ion Binding Heme Binding Regulation Of Sequestering Of Calcium Ion Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Olefinic Compound Metabolic Process Pressure Natriuresis G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Arachidonate Omega-hydroxylase Activity Cytochrome Metabolic Process Leukotriene B4 Catabolic Process Leukotriene B4 Metabolic Process Leukotriene-B4 20-monooxygenase Activity Alkane 1-monooxygenase Activity Vitamin E Metabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Positive Regulation Of Nuclear Cell Cycle DNA Replication Phospholipase C-activating Serotonin Receptor Signaling Pathway Long-chain Fatty Acid Catabolic Process Serotonin Binding Serotonin Receptor Signaling Pathway Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Activity Neural Crest Cell Differentiation GTPase Inhibitor Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen G Protein-coupled Serotonin Receptor Activity Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Body Fluid Levels
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