SLC6A1 and OXNAD1

		SLC6A1	OXNAD1
Description		solute carrier family 6 member 1	oxidoreductase NAD binding domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Cell Projection Neuronal Cell Body Synapse Presynapse GABA-ergic Synapse	Mitochondrion
	Molecular Function	Amino Acid:sodium Symporter Activity Gamma-aminobutyric Acid:sodium:chloride Symporter Activity Protein Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Symporter Activity Sodium:chloride Symporter Activity Transmembrane Transporter Activity Metal Ion Binding	Protein Binding Oxidoreductase Activity
	Biological Process	Amino Acid Transmembrane Transport Neurotransmitter Transport Amino Acid Transport Chemical Synaptic Transmission Memory Associative Learning Sodium Ion Transmembrane Transport Synapse Organization Gamma-aminobutyric Acid Reuptake Gamma-aminobutyric Acid Import Inorganic Anion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Neurotransmitter Reuptake Transport Across Blood-brain Barrier Chloride Transmembrane Transport
Pathways		SLC-mediated transport of neurotransmitters Reuptake of GABA
Drugs		Tiagabine Guvacine
Diseases
GWAS		Body fat percentage ( 31752434) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Loneliness (linear analysis) ( 27629369) Longitudinal alcohol consumption ( 26081443) Lung function ( 31902109) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554)	Night sleep phenotypes ( 27126917)
Interacting Genes		7 interacting genes: ARFGAP1 DRD2 HSF2BP HTR6 HUNK SNCA STX1A	4 interacting genes: CAPNS2 FKBP7 FSD2 IFT20
Entrez ID		6529	92106
HPRD ID		00664	14446
Ensembl ID		ENSG00000157103	ENSG00000154814
Uniprot IDs		A0A2R8Y4I3 B7Z3C5 P30531	C9JLB7 Q96HP4
PDB IDs		7SK2 7Y7V 7Y7W 7Y7Y 7Y7Z
Enriched GO Terms of Interacting Partners?		Regulation Of Catecholamine Secretion Dopamine Uptake Involved In Synaptic Transmission Regulation Of Amine Transport Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Transport Catecholamine Uptake Dopamine Uptake SNARE Complex Assembly Synaptic Transmission, Dopaminergic Synapse Synaptic Vesicle Membrane Behavioral Response To Cocaine Dopamine Transport Neurotransmitter Reuptake Positive Regulation Of Synaptic Transmission Regulation Of Neurotransmitter Uptake Positive Regulation Of Neurotransmitter Secretion Regulation Of Dopamine Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Vesicle-mediated Transport Monoamine Transport Neurotransmitter Uptake Dopamine Metabolic Process Response To Iron Ion Synaptic Vesicle Exocytosis Synaptic Vesicle Endocytosis Telencephalon Cell Migration Response To Cocaine Catecholamine Metabolic Process Presynaptic Endocytosis Forebrain Cell Migration Positive Regulation Of Secretion By Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Chemical Synaptic Transmission Axon Terminus Regulation Of Endocytosis Positive Regulation Of Secretion Excitatory Postsynaptic Potential Trans-synaptic Signaling Biogenic Amine Metabolic Process Synaptic Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity SNARE Binding Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Myosin Head/neck Binding Receptor Internalization	Gamma-aminobutyric Acid:sodium:chloride Symporter Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Gamma-aminobutyric Acid Import Amino Acid:sodium Symporter Activity Gamma-aminobutyric Acid Transport Acidic Amino Acid Transport Inorganic Anion Import Across Plasma Membrane Neurotransmitter Transport Transport Across Blood-brain Barrier Amino Acid Transmembrane Transport Symporter Activity Associative Learning Taurine:sodium Symporter Activity Taurine Transmembrane Transporter Activity Opsin Transport Intraciliary Transport Particle GABA-ergic Synapse Sodium:chloride Symporter Activity Gamma-aminobutyric Acid Reuptake Alanine Transmembrane Transporter Activity Kinociliary Basal Body Amino Acid Transport COPII-coated Vesicle Budding Import Across Plasma Membrane Sodium Ion Transmembrane Transport Taurine Transmembrane Transport MRF Binding Calpain Complex Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Dendrite Terminus Opsin Binding Learning Sodium Ion Transport
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