BCL11B and WDR25

		BCL11B	WDR25
Description		BCL11 transcription factor B	WD repeat domain 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus SWI/SNF Complex Neuron Projection
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Keratinocyte Development Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Axonogenesis Negative Regulation Of Cell Population Proliferation Post-embryonic Development Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Regulation Of Lipid Metabolic Process Striatal Medium Spiny Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Differentiation Post-embryonic Camera-type Eye Development T Cell Differentiation In Thymus T Cell Receptor V(D)J Recombination Hematopoietic Stem Cell Migration Odontogenesis Of Dentin-containing Tooth Positive T Cell Selection Skin Development Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Thymus Development T Cell Apoptotic Process Negative Regulation Of T Cell Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Olfactory Bulb Axon Guidance Lymphoid Lineage Cell Migration Into Thymus
Pathways		Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Airway wall thickness ( 25517131) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic stiffness ( 22068335) Bipolar disorder ( 34002096 31043756) Brain morphology (MOSTest) ( 32665545) Corneal curvature ( 22969067) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medial thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Posterior thalamic nuclei volume ( 34006833) Proximal colorectal cancer ( 33632709) Red blood cell count ( 32888494) Schizophrenia ( 30285260 29483656 28991256 25056061) Staphylococcus aureus infection ( 24847357) Systolic blood pressure night-to-day ratio in hypertension ( 29973135) Triglyceride levels in HIV infection ( 33109212) Waist circumference ( 34074324)	Menarche (age at onset) ( 25231870 27182965) Refractive error ( 32231278) Walking pace ( 33128006)
Interacting Genes		5 interacting genes: CBX5 NR2F1 NR2F2 SP1 SUV39H1	31 interacting genes: ACTMAP AKAP8L CNFN CYSRT1 DVL3 FAM168B FHL3 FOXI1 GOLGA6L9 HSF2BP KRT31 KRT34 KRT40 KRTAP12-3 KRTAP15-1 KRTAP3-1 KRTAP6-3 LDOC1 LNX1 MKRN3 NBPF19 NOTCH2NLA NOTCH3 PFDN5 PNMA1 PRDM14 PSME3 TEPSIN TRIM23 UBXN11 ZNF34
Entrez ID		64919	79446
HPRD ID		05950	14649
Ensembl ID		ENSG00000127152	ENSG00000176473
Uniprot IDs		L8B567 L8B7P7 L8B862 L8B8F6 Q9C0K0	A0A384NPW5 Q64LD2
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Transcription Repressor Complex Cellular Response To Wortmannin Heterochromatin Nuclear Receptor Activity Radial Pattern Formation Evoked Excitatory Postsynaptic Potential Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Response To Wortmannin Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Cellular Response To Zinc Ion Starvation Regulation Of Endothelial Cell Proliferation Histone H3K9 Trimethyltransferase Activity Chromosome, Centromeric Region Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation ENoSc Complex RDNA Heterochromatin Negative Regulation Of RNA Biosynthetic Process Lymphatic Endothelial Cell Fate Commitment Cellular Response To Starvation Negative Regulation Of Nucleobase-containing Compound Metabolic Process RDNA Heterochromatin Formation Retinoic Acid-responsive Element Binding Regulation Of Endothelial Cell Migration Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose Response To Starvation Histone H3K9 Methyltransferase Activity Intracellular Receptor Signaling Pathway Maternal Placenta Development Regulation Of DNA-templated Transcription Transcription Cis-regulatory Region Binding Rhythmic Process Regulation Of RNA Biosynthetic Process Cellular Response To Nutrient Levels Nuclear Lamina Facultative Heterochromatin Formation Epigenetic Regulation Of Gene Expression Epigenetic Programming In The Zygotic Pronuclei Chromatin Silencing Complex DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Lymph Vessel Development Trophoblast Giant Cell Differentiation Interneuron Migration	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Structural Molecule Activity Intermediate Filament Organization
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