CSRNP1 and PRPF18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CSRNP1	PRPF18
Description		cysteine and serine rich nuclear protein 1	pre-mRNA processing factor 18
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Post-embryonic Development Positive Regulation Of Transcription By RNA Polymerase II Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Brain-derived neurotrophic factor levels ( 33345186) Chronic lymphocytic leukemia ( 26956414) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Platelet count ( 32888494) Plateletcrit ( 32888494) Social communication problems ( 24564958)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) Craniofacial microsomia ( 26853712) Lupus nephritis in systemic lupus erythematosus ( 24925725) Post bronchodilator FEV1/FVC ratio ( 26634245) Skin pigmentation ( 28300201)
Interacting Genes		6 interacting genes: AQP1 PPP1CA PRPF18 TCEANC ZNF417 ZNF587	81 interacting genes: AGTRAP AMOTL2 AP2M1 ASCC2 BEGAIN BICD2 BLZF1 CADPS CALCOCO2 CARD10 CARD9 CBY2 CCDC102B CCDC136 CCDC150 CCDC57 CCNC CDR2 CEP70 CSRNP1 DRC4 DVL3 EFHC2 EVI5L FERMT3 FSD2 GCC1 GOLGA2 GOLGA6L9 GPBP1 GRIPAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKBKG IKZF1 KANK2 KCTD7 KIFC3 KRT31 KRT34 KRT35 KRT39 KRT40 LDOC1 LZTS1 LZTS2 MCC MDFI MEOX2 MTUS2 NACC1 NECAB2 NINL NUTM1 NUTM2F OSBPL3 PDE9A PFDN5 PIBF1 PICK1 PLEKHG4 PNMA1 PPIH PRKAR1B RHOU RINT1 SCHIP1 SPRED1 STX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TSNAX TSNAXIP1 UBXN11 ZNF526 ZNF639
Entrez ID		64651	8559
HPRD ID		07347	05407
Ensembl ID		ENSG00000144655	ENSG00000165630
Uniprot IDs		Q96S65	Q99633
PDB IDs			2DK4
Enriched GO Terms of Interacting Partners?		Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development U2-type Post-spliceosomal Complex Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Generation Of Catalytic Spliceosome For Second Transesterification Step Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Renal Water Absorption Carbon Dioxide Transmembrane Transporter Activity Positive Regulation Of Saliva Secretion Glomerulus Vasculature Development Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Transepithelial Water Transport Hydrogen Peroxide Transmembrane Transport Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Intracellularly CGMP-activated Cation Channel Activity Carbon Dioxide Transmembrane Transport Lipid Digestion Pancreatic Juice Secretion Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Ankyrin-1 Complex Renal Water Transport Glycerol Transmembrane Transport Nucleus Intracellular Water Homeostasis Regulation Of Saliva Secretion RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process PTW/PP1 Phosphatase Complex Ammonium Channel Activity Polyol Transmembrane Transport Response To Mercury Ion Double-strand Break Repair Via Alternative Nonhomologous End Joining Ammonium Transmembrane Transport Cellular Response To Salt Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Digestive System Process Epithelial Fluid Transport	Protein Binding Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament Organization Microtubule Identical Protein Binding Cytoskeleton Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process A2A Adenosine Receptor Binding Organelle Organization CBM Complex Cytosol Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
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