MEIG1 and NCOA5

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MEIG1	NCOA5
Name		meiosis/spermiogenesis associated 1	nuclear receptor coactivator 5
Structure
GO Annotations	Cellular Component	Manchette Nucleus Cytosol	Extracellular Space Nucleus Nucleoplasm Actin Cytoskeleton
	Molecular Function	Protein Binding	Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding
	Biological Process	Spermatogenesis Sperm Axoneme Assembly Intracellular Protein Localization Cell Differentiation Manchette Assembly	Negative Regulation Of Transcription By RNA Polymerase II Insulin Receptor Signaling Pathway Regulation Of Signal Transduction Glucose Homeostasis Negative Regulation Of Insulin Receptor Signaling Pathway
Drugs		None	17alpha-Estriol
GWAS		Metabolite levels ( 23823483 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 )	Crohn's disease ( 28067908 ) Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831 ) Follicular lymphoma or multiple sclerosis ( 31407831 ) HDL cholesterol levels ( 32203549 ) Hodgkin's lymphoma ( 30194254 ) Inflammatory bowel disease ( 28067908 ) Marginal zone lymphoma or multiple sclerosis ( 31407831 ) Multiple sclerosis ( 21833088 31604244 ) Systemic lupus erythematosus ( 28714469 ) Tonsillectomy ( 27182965 28928442 )
Interacting Genes		3 interacting genes: NCOA5 PACRG SPAG16	19 interacting genes: ACOT7 ATOSB CCDC57 CDC37 GORASP2 HTATIP2 KANK2 KHDRBS2 KHDRBS3 MEIG1 NR1D2 NTAQ1 PICK1 RAB30 SYT16 TSC22D1 TSGA10IP UBL5 ZNF326
Entrez ID		644890	57727
HPRD ID		18975	14813
Ensembl ID		ENSG00000197889	ENSG00000124160
Uniprot IDs		Q5JSS6	Q9HCD5
PDB IDs		6NDU 6NEP 6UCC	1V95 2J7X 2J7Y 4ZI1
GO Terms Enriched among Interactors		Sperm Flagellum Cilium Movement Motile Cilium Axonemal Central Apparatus Mucociliary Clearance Microtubule-based Movement Axonemal B Tubule Inner Sheath Cerebrospinal Fluid Circulation Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Cilium Extracellular Transport Epithelial Cilium Movement Involved In Extracellular Fluid Movement Respiratory System Process Microtubule-based Process Sperm Axoneme Assembly Developmental Process Involved In Reproduction Cellular Response To Unfolded Protein Alpha-tubulin Binding Axonemal Microtubule Cellular Response To Topologically Incorrect Protein Glial Cell Projection Hsp90 Protein Binding Beta-tubulin Binding Hsp70 Protein Binding Sperm Midpiece Manchette Axoneme Assembly	None