SUDS3 and COL6A3

		SUDS3	COL6A3
Description		SIN3A corepressor complex component SDS3	collagen type VI alpha 3 chain
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Sin3-type Complex	Extracellular Region Collagen Trimer Collagen Type VI Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Sarcolemma Extracellular Exosome Extracellular Vesicle
	Molecular Function	Histone Deacetylase Activity Protein Binding Enzyme Binding Histone Deacetylase Binding	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Apoptotic Process Regulation Of Gene Expression Substantia Nigra Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance	Cell Adhesion Muscle Organ Development Response To UV Response To Glucose Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Apoptotic Process
Pathways		HDACs deacetylate histones NoRC negatively regulates rRNA expression Ub-specific processing proteases Potential therapeutics for SARS	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases			Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Glucose homeostasis traits ( 25524916) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal sclerosis ( 25188341) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)	Abstraction and mental flexibility ( 31596458) Aging (time to event) ( 21782286) Chronic kidney disease ( 30226566) Coronary artery disease ( 33020668 29212778 30402224) Cortex volume ( 31530798) HDL cholesterol ( 26160806) Heel bone mineral density ( 30598549) Height ( 33713608) Hypertension ( 30226566) Intraocular pressure ( 29617998 29235454) Ischemic stroke ( 29930801) LDL cholesterol ( 26160806) Lung cancer ( 28604730) Myocardial infarction ( 30226566) Pulse pressure ( 27841878)
Interacting Genes		7 interacting genes: BRMS1 CSNK2A1 GOLGA2 HDAC1 LDOC1 PTEN SRPK1	2 interacting genes: DYSF MMP2
Entrez ID		64426	1293
HPRD ID		12196	00371
Ensembl ID		ENSG00000111707	ENSG00000163359
Uniprot IDs		Q9H7L9	B7ZW00 D9ZGF2 P12111 Q8N4Z1
PDB IDs			1KNT 1KTH 1KUN 2KNT 6SNK
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Cell Death Programmed Cell Death Apoptotic Process Meiotic Spindle Organization Meiotic Spindle Assembly Negative Regulation Of Stem Cell Population Maintenance NF-kappaB Binding Rhythmic Process Membraneless Organelle Assembly Organelle Assembly Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Motility Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Metabolic Process Spindle Assembly Enzyme Binding Krueppel-associated Box Domain Binding Negative Regulation Of Locomotion Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Collagen Type VI Trimer Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body PML Body Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Lysine Delactylase Activity Fungiform Papilla Formation Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Positive Regulation Of Protein Deacetylation Negative Regulation Of Phosphorylation Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Glycosylation Histone Deacetylase Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Circadian Rhythm Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Mitotic Spindle
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