SGCA and TUBG1

		SGCA	TUBG1
Description		sarcoglycan alpha	tubulin gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Cell-cell Junction Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma Membrane Raft	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Gamma-tubulin Ring Complex Nucleus Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Cell Leading Edge Ciliary Basal Body Neuron Projection Apical Part Of Cell Recycling Endosome Non-motile Cilium Mitotic Spindle Microtubule
	Molecular Function	Calcium Ion Binding Protein Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding Microtubule Nucleator Activity
	Biological Process	Muscle Contraction Muscle Organ Development	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Microtubule Nucleation Mitotic Spindle Organization Cytoplasmic Microtubule Organization
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Vinblastine
Diseases		Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Temporomandibular joint disorder ( 28081371) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		8 interacting genes: FN1 FSTL1 ITGB1BP2 SGCB SGCD SGTA SGTB TAF1	31 interacting genes: APP BRCA1 CEBPA CNTN2 CPAP CUL4A DDX41 ERCC3 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 OGT PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4
Entrez ID		6442	7283
HPRD ID		02525	01853
Ensembl ID		ENSG00000108823	ENSG00000131462
Uniprot IDs		A0A0S2Z4P8 A0A0S2Z4Q1 Q16586	P23258
PDB IDs			1Z5V 1Z5W 3CB2 6V5V 6V6S 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 7QJE 8Q62 8RX1 8VA2 8VRD 8VRJ 8VRK 9H9P
Enriched GO Terms of Interacting Partners?		TRC Complex Sarcoglycan Complex Dystroglycan Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Muscle Organ Development Dystrophin-associated Glycoprotein Complex Muscle Structure Development Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cardiac Muscle Cell Development Cardiac Cell Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Signaling Pathway Protein Targeting To Membrane Striated Muscle Cell Development Response To Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endothelial Cell Migration Negative Regulation Of Protein Autoubiquitination Microtubule Nucleator Activity Muscle Cell Development Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Identical Protein Binding Sarcolemma Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Calcium-independent Cell-matrix Adhesion BAT3 Complex Binding Acetyl-CoA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase I General Transcription Initiation Factor Activity Histone H4K16ac Reader Activity Polar Microtubule Negative Regulation Of Proteolysis	Microtubule-based Process Cytoskeleton Microtubule Cytoskeleton Organization Cytoskeleton Organization Microtubule Organelle Organization Microtubule Organizing Center Microtubule Nucleation Gamma-tubulin Binding Structural Constituent Of Cytoskeleton Centrosome Regulation Of Cell Cycle Positive Regulation Of Proteolysis Mitotic Cell Cycle Microtubule Cytoskeleton Gamma-tubulin Complex Intracellular Signal Transduction Cytoplasm Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Programmed Cell Death Signal Transduction Supramolecular Fiber Organization Protein Domain Specific Binding Spindle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Cell Cycle Process Spindle Pole Spindle Midzone Spindle Organization Positive Regulation Of Gene Expression Microtubule Organizing Center Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Regulation Of Response To Endoplasmic Reticulum Stress Midbody Regulation Of Protein Metabolic Process Microtubule Polymerization Or Depolymerization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Hemopoiesis Regulation Of Cellular Response To Stress Substrate Adhesion-dependent Cell Spreading
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