SMOC2 and SMOC1

Number of citations of the paper that reports this interaction (PubMedID 36178190)
90

Data Source:
BioGRID (pull down)

		SMOC2	SMOC1
Description		SPARC related modular calcium binding 2	SPARC related modular calcium binding 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Cell Periphery	Extracellular Region Basement Membrane Extracellular Space
	Molecular Function	Calcium Ion Binding Protein Binding Heparin Binding Metal Ion Binding Extracellular Matrix Binding	Calcium Ion Binding Protein Binding Heparin Binding Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Positive Regulation Of Endothelial Cell Migration Extracellular Matrix Organization Positive Regulation Of Vascular Wound Healing Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis	Eye Development Cell Differentiation Extracellular Matrix Organization Regulation Of Osteoblast Differentiation Limb Development
Pathways
Drugs
Diseases
GWAS		Circulating leptin levels in high cardiovascular risk ( 31766143) Copper levels ( 26025379) Corneal astigmatism ( 30306274) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Loneliness ( 27629369) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Pulse pressure ( 27841878 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 19890347) Waist circumference adjusted for body mass index ( 34021172)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Bone mineral density ( 24249740) Daytime sleep phenotypes ( 27126917) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Peripheral artery disease ( 31285632) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278) Triglyceride levels ( 30108155) Tuberculosis ( 24057671)
Interacting Genes		4 interacting genes: FBXO7 KRTAP5-1 SMOC1 TNC	10 interacting genes: CYSRT1 KRTAP1-1 KRTAP10-3 KRTAP10-8 NOTCH2NLA NR4A3 SMOC2 TCF4 TNC VGLL3
Entrez ID		64094	64093
HPRD ID		06244	12244
Ensembl ID		ENSG00000112562	ENSG00000198732
Uniprot IDs		Q9H3U7	Q9H4F8
PDB IDs
Enriched GO Terms of Interacting Partners?		Basement Membrane Perisynaptic Extracellular Matrix Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Extracellular Matrix Of Synaptic Cleft Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Bud Outgrowth Involved In Lung Branching Lewy Body Core Tenascin Complex Syndecan Binding Cellular Response To Prostaglandin D Stimulus Peripheral Nervous System Axon Regeneration Interstitial Matrix Mesenchymal-epithelial Cell Signaling Cellular Response To Vitamin D Branch Elongation Of An Epithelium Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Keratin Filament
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