SEL1L and RPL6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SEL1L	RPL6
Description		SEL1L adaptor subunit of SYVN1 ubiquitin ligase	ribosomal protein L6
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GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Derlin-1 Retrotranslocation Complex	Nucleus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Postsynaptic Density Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Ribonucleoprotein Granule Synapse Ribonucleoprotein Complex
	Molecular Function	Protein Binding	DNA Binding RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	Triglyceride Metabolic Process Notch Signaling Pathway Protein Secretion Protein Transport Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress ERAD Pathway Protein Stabilization	Cytoplasmic Translation Regulation Of DNA-templated Transcription Translation
Pathways		Pre-NOTCH Processing in Golgi ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Cadmium levels ( 26025379) Intraocular pressure ( 29617998) Lymphocyte count ( 32888494) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)	Blond vs. brown/black hair color ( 30531825) Blood pressure ( 21572416) Body mass index ( 26426971) Coffee consumption ( 29367735) Diastolic blood pressure ( 26390057) Esophageal cancer ( 21642993) Hip circumference adjusted for BMI ( 34021172) Systolic blood pressure ( 26390057)
Interacting Genes		2 interacting genes: HYOU1 RPL6	18 interacting genes: CSNK2A1 DUX4 EIF6 FBXO7 FGF2 FOXP1 H2AC4 IL7R IVNS1ABP LINC01554 MAP3K14 MT-ND1 NFKB2 NPAS2 OGT RPL29 SEL1L STAU1
Entrez ID		6400	6128
HPRD ID		07532	04745
Ensembl ID		ENSG00000071537	ENSG00000089009
Uniprot IDs		Q3ZCU6 Q9UBV2	Q02878 Q8TBK5
PDB IDs		8KES 8KET 8KEV	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Focal Adhesion Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Large Ribosomal Subunit Adenyl-nucleotide Exchange Factor Activity Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Chaperone Complex Endocytic Vesicle Lumen Smooth Endoplasmic Reticulum Regulation Of Cellular Response To Hypoxia Rough Endoplasmic Reticulum Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ATP-dependent Protein Folding Chaperone Negative Regulation Of Response To Endoplasmic Reticulum Stress Cytosolic Large Ribosomal Subunit Response To Ischemia Endoplasmic Reticulum	Sin3-type Complex Rhythmic Process Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Nucleoplasm Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Translation Negative Regulation Of Translational Initiation Response To Stress Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hsp90 Protein Binding Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Lymphocyte Apoptotic Process Regulation Of Hemopoiesis Hemopoiesis Assembly Of Large Subunit Precursor Of Preribosome Non-canonical NF-kappaB Signal Transduction Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Response To Mechanical Stimulus Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Development Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Cell Development Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Leukocyte Apoptotic Process Interleukin-7 Receptor Activity Regulation Of Glycolytic Process Bcl3/NF-kappaB2 Complex
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