SEL1L

Description		SEL1L adaptor subunit of SYVN1 ubiquitin ligase
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GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Derlin-1 Retrotranslocation Complex
	Molecular Function	Protein Binding
	Biological Process	Triglyceride Metabolic Process Notch Signaling Pathway Protein Secretion Protein Transport Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress ERAD Pathway Protein Stabilization
Pathways		Pre-NOTCH Processing in Golgi ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Cadmium levels ( 26025379) Intraocular pressure ( 29617998) Lymphocyte count ( 32888494) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		2 interacting genes: HYOU1 RPL6
Entrez ID		6400
HPRD ID		07532
Ensembl ID		ENSG00000071537
Uniprot IDs		Q3ZCU6 Q9UBV2
PDB IDs		8KES 8KET 8KEV
Enriched GO Terms of Interacting Partners?		Focal Adhesion Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Large Ribosomal Subunit Adenyl-nucleotide Exchange Factor Activity Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Chaperone Complex Endocytic Vesicle Lumen Smooth Endoplasmic Reticulum Regulation Of Cellular Response To Hypoxia Rough Endoplasmic Reticulum Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ATP-dependent Protein Folding Chaperone Negative Regulation Of Response To Endoplasmic Reticulum Stress Cytosolic Large Ribosomal Subunit Response To Ischemia Endoplasmic Reticulum
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