- and PLCB2

		-	PLCB2
Description		schizophrenia disorder 10 (periodic catatonia)	phospholipase C beta 2
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol G-protein Beta/gamma-subunit Complex Neuronal Dense Core Vesicle
	Molecular Function		Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phospholipid Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding Phosphatidylinositol Phospholipase C Activity
	Biological Process		Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Lipid Metabolic Process Phospholipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste Release Of Sequestered Calcium Ion Into Cytosol
Pathways			PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs
Diseases
GWAS		HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)
Interacting Genes			7 interacting genes: GNAQ MAP2K3 MAP2K6 NHERF1 SNCA TRPC3 TRPM7
Entrez ID		63944	5330
HPRD ID			04985
Ensembl ID			ENSG00000137841
Uniprot IDs			Q00722 Q59F77 Q9BVT6
PDB IDs			2FJU 2ZKM
Enriched GO Terms of Interacting Partners?		G-protein Beta/gamma-subunit Complex Phosphatidylinositol Phospholipase C Activity Sensory Perception Of Bitter Taste Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Neuronal Dense Core Vesicle Phospholipase C Activity Phosphatidylinositol-mediated Signaling G-protein Beta/gamma-subunit Complex Binding Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Sensory Perception Of Taste Negative Regulation Of Sequestering Of Calcium Ion Phosphoric Diester Hydrolase Activity Release Of Sequestered Calcium Ion Into Cytosol Detection Of Chemical Stimulus Involved In Sensory Perception Calcium Ion Transmembrane Import Into Cytosol Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol Metabolic Process Phospholipid Binding Regulation Of Sequestering Of Calcium Ion Detection Of Chemical Stimulus Sensory Perception Of Chemical Stimulus Detection Of Stimulus Involved In Sensory Perception Calcium Ion Transmembrane Transport Glycerophospholipid Metabolic Process Lipid Catabolic Process Detection Of Stimulus Calcium Ion Transport Glycerolipid Metabolic Process Phospholipid Metabolic Process	Response To Testosterone Regulation Of Phosphorus Metabolic Process NLRP1 Inflammasome Complex Assembly Response To Ketone Regulation Of Protein Kinase Activity Cellular Response To UV-B Regulation Of Phosphorylation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Calcium Channel Activity Response To Lipid MAP Kinase Kinase Activity Regulation Of Kinase Activity Response To Magnesium Ion Response To Light Stimulus Detection Of Abiotic Stimulus Response To UV-B Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Kinase Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Protein Serine Kinase Activity Regulation Of MAPK Cascade Extracellular Matrix Binding GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Regulation Of Cell Communication Response To Radiation Regulation Of Signaling Phototransduction Cellular Response To Stress S-methyl-5-thioadenosine Phosphorylase Activity Negative Regulation Of Centriole-centriole Cohesion Protein Serine/threonine Kinase Activity Cardiac Muscle Contraction Regulation Of Protein Phosphorylation Canonical Inflammasome Complex Assembly Pyroptotic Inflammatory Response Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Protein Kinase Inhibitor Activity Inorganic Ion Homeostasis Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Fibroblast Migration Calcium Ion Transmembrane Transport Renal Phosphate Ion Absorption Protein-containing Complex Assembly
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