FAM217B and POLR2L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM217B	POLR2L
Description		family with sequence similarity 217 member B	RNA polymerase II, I and III subunit L
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol
	Molecular Function	Protein Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process		DNA-templated Transcription Regulation Of Transcription By RNA Polymerase I Transcription By RNA Polymerase I Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III
Pathways			Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Delirium ( 29631748)	Pulse pressure ( 30578418)
Interacting Genes		20 interacting genes: AIRIM ANKS1A ANP32B BANP CATSPERT CCDC102B CDCA7L EXOC8 HMBOX1 L3MBTL2 MAD2L2 MYLIP POLR2L SMARCE1 SPANXN3 SUOX TCEANC TLE5 TTC19 ZBTB16	27 interacting genes: AGR2 BANP CCDC85B CCN3 CHEK2 COIL EXOSC5 FAM217B L3MBTL3 NACC1 NFKBIB PHC2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2H PSMA6 REL RPAP1 SNX7 SPAG5 THAP1 TP53BP2 TRIP13 ZBTB14
Entrez ID		63939	5441
HPRD ID		12758	01155
Ensembl ID		ENSG00000196227	ENSG00000177700
Uniprot IDs		B4E2D0 Q9NTX9	P62875
PDB IDs			5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7LBM 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9EHZ 9EI1 9EI3 9EI4 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?			RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-templated Transcription DNA-directed RNA Polymerase Activity Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Nucleoplasm RNA Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA Binding Nucleus Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process 5'-3' RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process RNA Polymerase I Complex RNA Polymerase III Complex Nucleotidyltransferase Activity Positive Regulation Of Organelle Assembly Nucleolus Positive Regulation Of Autophagosome Assembly Positive Regulation Of Vacuole Organization NF-kappaB Binding Identical Protein Binding Purine Ribonucleoside Triphosphate Binding
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