SDHC and ARHGDIA

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SDHC	ARHGDIA
Gene Name		succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	Rho GDP dissociation inhibitor (GDI) alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex II Integral Component Of Membrane Respiratory Chain Complex II	Immunological Synapse Cytosol Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Succinate Dehydrogenase Activity Electron Carrier Activity Heme Binding Metal Ion Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Aerobic Respiration Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Movement Of Cell Or Subcellular Component Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Negative Regulation Of Cell Migration Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)	Rho GTPase cycle Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis Axonal growth stimulation Signaling by Rho GTPases p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		3 interactors: ARHGDIA MDM2 XRCC6	36 interactors: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B FEN1 HAAO HERPUD1 IKBKG JUP MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		6391	396
HPRD ID		03878	03565
Ensembl ID			ENSG00000141522
Uniprot IDs		Q99643	J3QQX2 J3QW41 P52565
PDB IDs			1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0
Enriched GO Terms of Interacting Partners?		Cellular Response To Radiation Cellular Response To UV-C Cellular Response To Vitamin B1 Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Hyperosmotic Salinity Response Traversing Start Control Point Of Mitotic Cell Cycle Response To Vitamin B1 Response To Ether Cellular Response To X-ray Positive Regulation Of Neurogenesis Establishment Of Integrated Proviral Latency Response To Radiation Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Response To UV-C Positive Regulation Of Cell Development Cellular Response To Salt Stress Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Viral Process Positive Regulation Of Protein Export From Nucleus DNA Ligation Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Magnesium Ion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Antibiotic Negative Regulation Of Cell Cycle Arrest Regulation Of Neurogenesis Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Toxic Substance Hyperosmotic Response Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Metabolic Process Protein Destabilization Regulation Of Protein Localization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Cellular Response To Estrogen Stimulus V(D)J Recombination Cellular Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Regulation Of Protein Export From Nucleus Regulation Of Cell Development Positive Regulation Of Cell Differentiation Response To X-ray Enzyme Linked Receptor Protein Signaling Pathway	Response To Stress Response To Stimulus Cellular Response To Stimulus Homeostatic Process Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Intracellular Signal Transduction Positive Regulation Of Cell Death Signaling Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Component Biogenesis Cell Communication Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Projection Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Catalytic Activity Regulation Of DNA Replication Positive Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Programmed Cell Death Small GTPase Mediated Signal Transduction Blood Coagulation Regulation Of Telomere Maintenance Hemostasis Response To Abiotic Stimulus Regulation Of Signaling Telomere Maintenance Regulation Of Catalytic Activity Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Lamellipodium Assembly Response To Wounding Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Organic Substance
Tagcloud ?		6j acetaminophen alleviating aminotransferase apap benzoquinoneimine bioactivation bypassing centrilobular crisis electrons energized hepatology hepatotoxicity insufficiently intraperitoneally massive mb methylene nanoscale napqi overdose permeant reconstituted respiration restoring sdha succinate triphosphate	3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally hence intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators repression separate serve snai2 untranslated utr
Tagcloud (Difference) ?		6j acetaminophen alleviating aminotransferase apap benzoquinoneimine bioactivation bypassing centrilobular crisis electrons energized hepatology hepatotoxicity insufficiently intraperitoneally massive mb methylene nanoscale napqi overdose permeant reconstituted respiration restoring sdha succinate triphosphate	3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally hence intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators repression separate serve snai2 untranslated utr
Tagcloud (Intersection) ?