SCN10A and SCLT1

Number of citations of the paper that reports this interaction (PMID 15797711)
7

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SCN10A	SCLT1
Gene Name		sodium channel, voltage gated, type X alpha subunit	sodium channel and clathrin linker 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex C-fiber Extracellular Vesicular Exosome	Centrosome Centriole Cytosol Extracellular Vesicular Exosome Clathrin Complex Ciliary Transition Fiber
	Molecular Function	Voltage-gated Sodium Channel Activity	Protein C-terminus Binding Sodium Channel Regulator Activity Clathrin Binding
	Biological Process	Regulation Of Heart Rate Sodium Ion Transport Sensory Perception Neuronal Action Potential Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Membrane Depolarization During Action Potential AV Node Cell To Bundle Of His Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication	Organelle Organization Cilium Assembly Clustering Of Voltage-gated Sodium Channels
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions	Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs		Lidocaine Ropivacaine Bupivacaine Hexylcaine Dibucaine Dyclonine Procaine Proparacaine Oxybuprocaine Cocaine Mepivacaine Levobupivacaine Benzocaine Chloroprocaine Orphenadrine Lacosamide
Diseases
GWAS		Atrioventricular conduction ( 21041692) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062061 20062063) PR interval ( 20062060 23139255) Systemic lupus erythematosus ( 23273568) Ventricular conduction ( 21076409)
Protein-Protein Interactions		2 interactors: ACTB SCLT1	4 interactors: CALM1 IKBKG LNX1 SCN10A
Entrez ID		6336	132320
HPRD ID		09188	08700
Ensembl ID		ENSG00000185313	ENSG00000151466
Uniprot IDs		Q9Y5Y9	Q96NL6
PDB IDs
Enriched GO Terms of Interacting Partners?		Clustering Of Voltage-gated Sodium Channels Neuronal Ion Channel Clustering Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Neuron Maturation Substantia Nigra Development Platelet Aggregation Generation Of Neurons Neural Nucleus Development 'de Novo' Posttranslational Protein Folding Neurogenesis Retina Homeostasis 'de Novo' Protein Folding ATP-dependent Chromatin Remodeling Cell Development Cellular Component Assembly Midbrain Development Adherens Junction Organization Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Nervous System Development Anatomical Structure Morphogenesis Cell Maturation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway	Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Muscle Contraction Regulation Of Ion Homeostasis Regulation Of Heart Contraction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Fc Receptor Signaling Pathway Regulation Of High Voltage-gated Calcium Channel Activity AV Node Cell To Bundle Of His Cell Communication Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Bundle Of His Cell To Purkinje Myocyte Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ion Transmembrane Transport Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Transferase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Ion Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of NF-kappaB-inducing Kinase Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Neuronal Action Potential
Tagcloud ?		arrhythmias cardiac clustered coactivator colocalized conduction congenital contraction disrupts electrical enhancer enhancers functionally gata4 helps humans impulse nkx2 noncoding occupation perturbations predisposition relies repressed scn5a snp tbx3 tbx5 uncovering
Tagcloud (Difference) ?		arrhythmias cardiac clustered coactivator colocalized conduction congenital contraction disrupts electrical enhancer enhancers functionally gata4 helps humans impulse nkx2 noncoding occupation perturbations predisposition relies repressed scn5a snp tbx3 tbx5 uncovering
Tagcloud (Intersection) ?