SCN10A

Description		sodium voltage-gated channel alpha subunit 10
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Axon Monoatomic Ion Channel Complex Presynaptic Membrane Extracellular Exosome Clathrin Complex Glutamatergic Synapse
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Transmembrane Transporter Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Regulation Of Heart Rate Monoatomic Ion Transport Sodium Ion Transport Sensory Perception Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential AV Node Cell Action Potential Bundle Of His Cell Action Potential Regulation Of Presynaptic Membrane Potential
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Ranolazine Topiramate Lidocaine Ropivacaine Bupivacaine Valproic acid Hexylcaine Cinchocaine Lamotrigine Carbamazepine Dyclonine Procaine Oxcarbazepine Proparacaine Oxybuprocaine Cocaine Mepivacaine Levobupivacaine Promethazine Benzocaine Chloroprocaine Orphenadrine Brivaracetam Lacosamide Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Atrioventricular conduction ( 21041692) Brugada syndrome ( 35210625 32619740 23872634) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062061 25055868 20062063) Electrocardiographic traits (multivariate) ( 32602732) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) P wave duration ( 24850809 28794112) Physical health related quality of life ( 33578652) PR interval ( 21347284 20062060 32439900 30679814 30046033 23139255 29127183 25035420) PR segment duration ( 24850809) Pulse pressure ( 30224653 30578418) QRS duration ( 30012220 21076409 25035420 31251759 30679814 27577874 27659466) QT interval ( 24952745 29874175) Sick sinus syndrome ( 33580673) Systemic lupus erythematosus ( 23273568) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149)
Interacting Genes		3 interacting genes: ACTB NEDD4 SCLT1
Entrez ID		6336
HPRD ID		09188
Ensembl ID		ENSG00000185313
Uniprot IDs		Q9Y5Y9
PDB IDs		7WE4 7WEL 7WFR 7WFW 9DBK 9DBL 9DBM 9DBN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Formation Of Structure Involved In A Symbiotic Process Cell Projection Organization Regulation Of Norepinephrine Uptake Channel Inhibitor Activity Regulation Of Transepithelial Transport Protein Localization To Adherens Junction Dense Body Transporter Regulator Activity Morphogenesis Of A Polarized Epithelium Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Clustering Of Voltage-gated Sodium Channels Structural Constituent Of Postsynaptic Actin Cytoskeleton Nitric-oxide Synthase Regulator Activity Sodium Channel Inhibitor Activity Ciliary Transition Fiber Clathrin Complex BBAF Complex Tat Protein Binding Brahma Complex Nitric-oxide Synthase Binding NBAF Complex Regulation Of Cellular Localization Apical Protein Localization Postsynaptic Actin Cytoskeleton RSC-type Complex Adherens Junction Assembly Postsynaptic Actin Cytoskeleton Organization NpBAF Complex GBAF Complex Cell Junction Organization Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Endocardial Cushion Development Potassium Channel Inhibitor Activity Neuronal Ion Channel Clustering Protein Localization To Cell-cell Junction Calyx Of Held Glutamatergic Synapse Proline-rich Region Binding Receptor Catabolic Process RNA Polymerase Binding
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